PMID: 25792795Dec 1, 2006Paper

Mechanisms of a tumor marker, glutathione transferase P, expression during hepatocarcinogenesis of the rat

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Masami Muramatsu, Masaharu Sakai

Abstract

The molecular mechanism of any tumor marker expression may shed a light on the mechanism of the particular tumorigenesis. This idea in mind, we have been pursuing the mechanism of specific induction of the placental type glutathione transferase (GST-P) gene during hepatocarcinogenesis of the rat. Making use of advanced technologies of molecular biology including proteomic analysis, gene cloning and production of specific transgenic rats etc., we were able to identify the enhancer and the activator proteins responsible for this tumor marker expression. Negative regulatory regions and modulatory proteins were also found. The overview of this long range study and the future outlook of the problem will be discussed.

References

Aug 30, 1991·Biochemical and Biophysical Research Communications·M ImagawaM Muramatsu
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M SakaiM Muramatsu
Aug 3, 1994·Biochemical Pharmacology·A K Jaiswal
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N C AndrewsS H Orkin
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S MorimuraM Muramatsu
Oct 18, 2000·Free Radical Biology & Medicine·A K Jaiswal
Aug 21, 2002·Biological & Pharmaceutical Bulletin·Atsuhiro TanabeMasayoshi Imagawa
Jan 10, 2006·Methods in Enzymology·Masaharu Sakai, Masami Muramatsu
Jan 13, 2006·The Journal of Biological Chemistry·Hiromi IkedaMasaharu Sakai

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Citations

Apr 17, 2007·Biochemical and Biophysical Research Communications·Masaharu Sakai, Masami Muramatsu

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