PMID: 7543136Aug 1, 1995Paper

Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo

The Journal of Experimental Medicine
S J KhouryH L Weiner

Abstract

Experimental autoimmune encephalomyelitis (EAE), an experimental model for the study of multiple sclerosis, is an autoimmune disease of the central nervous system that can be induced in a number of species by immunization with myelin basic protein (MBP). MBP-reactive CD4+ T cells, predominantly expressing the V beta 8.2 T cell receptor (TCR), migrate from the peripheral lymphoid organs and initiate the inflammatory response in the brain. We have previously shown that a single intrathymic injection of MBP or its major encephalitogenic peptide (p71-90), but not a nonencephalitogenic peptide (p21-40), induces antigen-specific systemic tolerance and inhibits the induction of EAE in Lewis rats. In this study, we investigated the mechanisms of induction and maintenance of acquired thymic tolerance in this model. First, we investigated which thymic cell is responsible for "induction" of systemic tolerance. Thymic dendritic-enriched cells, isolated by plastic adherence, when incubated in vitro with p71-90 and injected intravenously into Lewis rats, were capable of preventing the development of EAE, but his protection was lost in thymectomized recipients. In addition, intravenous injection of thymic dendritic cells isolated from animals...Continue Reading

References

Feb 1, 1992·The Journal of Clinical Investigation·S B Koevary, M Blomberg
Mar 1, 1991·The Journal of Experimental Medicine·M InabaS Ikehara
Jan 1, 1991·Annual Review of Immunology·R M Steinman
May 1, 1991·The Journal of Experimental Medicine·D B AgusJ Sprent
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C V HardingE R Unanue
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S J ClarkA F Williams
Nov 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·E H Eylar
Jan 1, 1969·International Archives of Allergy and Applied Immunology·P C Dau, R D Peterson
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M E RussellM J Karnovsky

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Citations

Jan 1, 1997·International Journal of Clinical & Laboratory Research·N Perico, G Remuzzi
Sep 25, 2002·Transplantation Proceedings·A P Monaco
Nov 20, 1997·Transplantation Proceedings·J J Fung
Mar 19, 1999·Immunology Today·A W Thomson, L Lu
May 7, 1997·Transfusion Science·J Banchereau
Jan 28, 2003·Trends in Immunology·Irving Goldschneider, Robert E Cone
Jun 1, 1997·Immunology and Cell Biology·K Ni, H C O'Neill
Aug 19, 2010·Nature Reviews. Neurology·Manuel ComabellaJan D Lünemann
Jul 18, 2002·The Journal of Experimental Medicine·Kevin L LeggeHabib Zaghouani
Feb 13, 1996·Annals of the New York Academy of Sciences·S D HurstT A Barrett
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Apr 4, 2001·The Journal of Clinical Investigation·A M WaagaM H Sayegh
Mar 20, 2002·The Journal of Clinical Investigation·Steven R DuncanArgyrios N Theofilopoulos
Mar 17, 1999·The Journal of Clinical Investigation·B MurphyM H Sayegh
Dec 18, 2010·Respiratory Research·Masayuki HanaokaLaimute Taraseviciene-Stewart
Mar 20, 2009·Journal of the American Society of Nephrology : JASN·Ana Maria Waaga-GasserAnil Chandraker
Mar 1, 2000·Journal of Neuroimmunology·H LinkB G Xiao
Nov 26, 2009·Journal of Neuroimmunology·Roopali GandhiHoward L Weiner
Feb 15, 2000·Cytokine·M A Antonysamy, A W Thomson
Aug 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Marcus D SäemannGerhard J Zlabinger
May 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Haval ShirwanSherif Ibrahim
Jan 7, 2011·Immunology·Jim Hu, Yonghong Wan
Feb 25, 2015·Cellular Immunology·Abhishek TrigunaiteTrine N Jørgensen
Mar 15, 2006·International Reviews of Immunology·Hee-Kap Kang, Syamal K Datta

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