Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024

Neurochemical Research
A F AmbrósioA P Carvalho

Abstract

Carbamazepine (CBZ) has been extensively used in the treatment of epilepsy, as well as in the treatment of neuropathic pain and affective disorders. However, the mechanisms of action of this drug are not completely elucidated and are still a matter of debate. Since CBZ is not very effective in some epileptic patients and may cause several adverse effects, several antiepileptic drugs have been developed by structural variation of CBZ, such as oxcarbazepine (OXC), which is used in the treatment of epilepsy since 1990. (S)-(-)-10-acetoxy-10,11-dihydro-5H-dibenz [b,f]azepine-5-carboxamide (BIA 2-093) and 10,11-dihydro-10-hydroxyimino-5H-dibenz[b,f] azepine-5-carboxamide (BIA 2-024), which were recently developed by BIAL, are new putative antiepileptic drugs, with some improved properties. In this review, we will focus on the mechanisms of action of CBZ and its derivatives, OXC, BIA 2-093 and BIA 2-024. The available data indicate that the anticonvulsant efficacy of these AEDs is mainly due to the inhibition of sodium channel activity.

Citations

Feb 24, 2004·CNS Spectrums·Po W WangCecylia Nowakowska
Sep 9, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Wenhua XiaoGary J Bennett
Apr 10, 2010·Current Medical Research and Opinion·Teresa NunesPatricio Soares-da-Silva
Nov 19, 2011·Expert Review of Neurotherapeutics·Markus Rauchenzauner, Gerhard Luef
Nov 30, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Andrea Susan GiardinaDaniel R Eckermann
Feb 17, 2015·Epilepsia·Elizabeth García-PérezJohn F Wesseling
May 7, 2016·Biological & Pharmaceutical Bulletin·Wataru MatsuuraShogo Tokuyama
Jun 3, 2018·BMC Pregnancy and Childbirth·Alastair Macfarlane, Trisha Greenhalgh
Oct 13, 2019·Metabolic Brain Disease·Asmat Ullah KhanSaeed Ahmad
Sep 16, 2005·Expert Review of Neurotherapeutics·Richard H Weisler
Apr 28, 2007·Expert Opinion on Investigational Drugs·Nicholas James Hargus, Manoj Kumar Patel
Sep 1, 2009·Expert Opinion on Investigational Drugs·Victoria D KirchhoffRoger S McIntyre
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Anindya BhattacharyaSandra R Chaplan
Apr 14, 2010·Expert Opinion on Therapeutic Patents·Valentina ZulianiGabriele Costantino
Mar 13, 2012·Expert Opinion on Pharmacotherapy·Philip N Patsalos, David J Berry
Jan 25, 2013·American Journal of Therapeutics·Harry KarydesSean M Bryant
Aug 5, 2016·Environmental Science and Pollution Research International·A González-MiraA Torreblanca
Oct 24, 2014·Bulletin of Experimental Biology and Medicine·D I ProkhorovR D Seifulla
Jun 10, 2017·Alternatives to Laboratory Animals : ATLA·Abdal-Jabbar Al-RubaiMargaret K Pratten
Feb 25, 2018·Environmental Toxicology and Chemistry·Kristine M HammillJoanna Y Wilson
Feb 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·André PereiraAngelina Pena
Jul 8, 2005·Psychopharmacology·Charles H LargeDonald C Goff
Apr 14, 2007·Bipolar Disorders·Galit ShaltielGalila Agam
Feb 9, 2008·Journal of Clinical Pharmacology·Claire SouppartSilke Appel-Dingemanse
May 16, 2017·Drug and Chemical Toxicology·Huma AkbarIlham Begum
Aug 5, 2016·International Journal of Molecular Sciences·Hueng-Chuen FanChing-Shiang Chi
May 4, 2018·Pain Practice : the Official Journal of World Institute of Pain·Haining DaiFrancis M Reynolds
Jun 7, 2018·Database : the Journal of Biological Databases and Curation·Charles Tapley HoytMartin Hofmann-Apitius
May 10, 2017·Frontiers in Pharmacology·Evangelia PassiaCaroline F Samer
Aug 16, 2019·Neurochemical Research·Christoffer MertzLasse K Bak
Nov 5, 2003·CNS Drugs·Gary McCleane
Aug 27, 2005·The Journal of Pharmacology and Experimental Therapeutics·Jacob C OngMark A Geyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.