Mechanisms of action of carcinogenic aromatic amines: an investigation using mutagenesis in bacteria

Chemico-biological Interactions
J D ScribnerN K Scribner


The mutagenicities of groups of N-acetoxy-N-arylacetamides, nitroarenes, arylamides and arylamines were determined in the Salmonella typhimurium tester stains TA98, TA1538, TA100, TA1535 and TA1537. Three broad classes of mutagenic activity were found, interpreted as follows: class A, including 2-naphthylamine, produced essentially only base-pair substitution without induction of error-prone repair; class B, including 4-aminobiphenyl, caused consideration induction of error-prone repair, accompanied by a lower level of frame shifting; class C, including N-acetoxy-2-acetamidofluorene, produced high levels of frame shifting, with some induction of error-prone repair. Correlation of these results with known reactions of certain aromatic amine derivatives with nucleosides and nucleic acids, and with molecular orbital calculations, suggests that the effect of class A is produced by small aromatic groups attached to extranuclear heteroatoms in DNA bases, the effect of class B is caused by large aromatic groups attached to extranuclear heteroatoms or by arylamines attached to C-8 of guanine, while the effect of class C is caused by arylamides attached to C-8 of guanine, probably rotating into the helix, as proposed by others. The data...Continue Reading


Jun 1, 1979·Chemico-biological Interactions·N K Scribner, J D Scribner
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesW E Durston

❮ Previous
Next ❯


Sep 1, 1982·Archives of Toxicology·B S Bock-HennigK W Bock
May 1, 1984·Mutation Research·G Klopman, H S Rosenkranz
Nov 1, 1982·Mutation Research·V W Mayer
Dec 1, 1981·Mutation Research·E J LaVoieD Hoffmann
Aug 1, 1985·Mutation Research·T SatoT Ishikawa
Jul 1, 1985·Chemico-biological Interactions·Y TsurutaP J O'Brien
Oct 15, 1982·Biochemical and Biophysical Research Communications·E C McCoyH S Rosenkranz
Oct 15, 1982·Biochemical and Biophysical Research Communications·F E Evans, D W Miller
Aug 26, 2014·International Archives of Occupational and Environmental Health·Kimiko TomiokaNorio Kurumatani
Jan 1, 1982·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·W M Draper, J C Street
Jan 1, 1985·Teratogenesis, Carcinogenesis, and Mutagenesis·G L White, R H Heflich
Jan 1, 1981·Environmental Mutagenesis·E C McCoyR Mermelstein
Jan 1, 1988·Environmental and Molecular Mutagenesis·R H HeflichF A Beland
May 16, 2018·Journal of Chromatographic Science·Shubo DongDeju Ye
May 1, 1982·Chemico-biological Interactions·K B LipkowitzF A Beland
Sep 6, 2012·Chemical Research in Toxicology·Igor ShamovskyPeter Sjö
Jun 21, 2018·Journal of Chemical Information and Modeling·Ryan W KungStacey D Wetmore

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.