PMID: 6168328Aug 10, 1981Paper

Mechanisms of action of cyclic nucleotides on a bursting pacemaker and silent neuron in Aplysia

Brain Research
P F Drake, S N Treistman

Abstract

Cyclic nucleotides are believed to mediate a long-lasting synaptic hyperpolarization in the bursting pacemaker neuron, R15, and are capable of inducing bursting pacemaker activity in the usually silent metacerebral giant cell. Steady state voltage clamp techniques were used to examine the alterations of membrane characteristics produced in these different cell types by cyclic nucleotides. In both cells, IBMX, a phosphodiesterase inhibitor, increased two components: (1) voltage-dependent sodium current and (2) slope conductance believed to reflect potassium flux. The effects of 8-benzylthio-cAMP were identical to those of IBMX in the metacerebral cell. In R15, 8-benzylthio-cAMP affected only the slope conductance. These results are discussed in terms of cyclic nucleotide of bursting pacemaker activity.

References

Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S N Treistman, I B Levitan
Jun 8, 1979·Brain Research·S N Treistman, P F Drake
Nov 1, 1972·Nature: New Biology·D S Farber, M R Klee
Mar 22, 1974·Brain Research·S N Treistman, J H Schwartz

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Citations

Nov 21, 1983·Brain Research·T L SeeligJ J Kendig
Jan 1, 1985·Progress in Biophysics and Molecular Biology·W B Adams, J A Benson
Jan 1, 1984·Progress in Neurobiology·K S Rózsa
Dec 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tej K PareekAshok B Kulkarni
Oct 16, 1983·Brain Research·J B AldenhoffD Swandulla
Dec 12, 2002·Diabetes·Patrick E MacDonaldMichael B Wheeler
Feb 14, 2006·Journal of Neurobiology·Jon W JackletDavid G Tieman
Mar 1, 1984·Clinical Endocrinology·J VanderpasC H Thilly

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