PMID: 8588221Dec 1, 1995Paper

Mechanisms of action of new immunosuppressive drugs

Therapeutic Drug Monitoring
R E Morris

Abstract

More immunosuppressive drugs than ever have recently graduated from the laboratory to extensive clinical trials of their safety and efficacy in transplant patients. None of these drugs is perfect, but they control different forms of rejection in stringent animal models more effectively than other immunosuppressants, and these novel molecules suppress the immune system far more specifically than steroids and regimens that cause lymphopenia. Cyclosporin A and FK506 are the only drugs that selectively inhibit T-cell proliferation by blocking cytokine synthesis. The primary action of rapamycin appears to be inhibition of the actions of cytokines and growth factors on T, B, and some nonimmune cells. T and B cells are more sensitive than nonimmune cells to the depletion of purines and pyrimidines caused by mizoribine, mycophenolate mofetil, brequinar sodium, and leflunomide. Nucleotide depletion causes interruption of DNA synthesis and glycosylation of adhesion molecules in immune cells. Further differentiation of T and B cells after proliferation into fully functional immune cells is inhibited by unknown mechanisms of brequinar and deoxyspergualin. On the basis of preclinical studies, these drugs may effectively suppress clinical re...Continue Reading

Citations

Jan 23, 2013·Lasers in Medical Science·Rodrigo G OliveiraFernando M Aarestrup
Oct 1, 1996·Clinical Biochemistry·N GoodyearS J Soldin
Dec 26, 2001·Transplantation Proceedings·D K GrangerUNKNOWN ERL B 302 Renal Transplant Study Group
Nov 16, 1996·Lancet·J J Lipsky
Jan 5, 2002·International Journal of Paediatric Dentistry·B WondimuT Modéer
Jun 26, 2001·Seminars in Dialysis·V R Peddi, M R First
Oct 26, 2010·Photomedicine and Laser Surgery·Rodrigo Guerra de OliveiraLuis Carlos Andrade
Dec 17, 2004·Journal of Clinical Pharmacology·Jaya PisupatiRaman Venkataramanan
Sep 15, 2007·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yan SunShi-guang Shan
Nov 21, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·R B Stein, S B Hanauer
Dec 9, 2010·Transplantation Proceedings·J M Campistol
Mar 29, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Salvatore Di PaoloLoreto Gesualdo
Aug 1, 1997·Seminars in Veterinary Medicine and Surgery (small Animal)·E Miller
Apr 29, 2009·The Journal of Comparative Neurology·Svitlana Garbuzova-DavisPaul R Sanberg
Apr 20, 2005·Dermatologic Clinics·Dana Kazlow SternMark Lebwohl
Jan 13, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Y W ChenK W Mollison
Jul 5, 2017·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Reza HajizadehNader D Nader
Nov 12, 2010·Therapeutic Drug Monitoring·Wei ZhaoEvelyne Jacqz-Aigrain
Jul 31, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D Z Cherney, J S Zaltzman
Sep 17, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S H Sacks
Dec 1, 1996·Current Opinion in Structural Biology·M A Navia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.