Mechanism(s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura

BMC Complementary and Alternative Medicine
Z A ZakariaM Z Salleh

Abstract

Muntingia calabura L. (family Muntingiaceae), commonly known as Jamaican cherry or kerukup siam in Malaysia, is used traditionally to treat various ailments. The aim of this study is to elucidate the possible underlying gastroprotective mechanisms of ethyl acetate fraction (EAF) of Muntingia calabura methanolic leaves extract (MEMC). MEMC and its fractions were subjected to HPLC analysis to identify and quantify the presence of its phyto-constituents. The mechanism of gastroptotection of EAF was further investigated using pylorus ligation-induced gastric lesion rat model (100, 250, and 500 mg/kg). Macroscopic analysis of the stomach, evaluation of gastric content parameters such as volume, pH, free and total acidity, protein estimation, and quantification of mucus were carried out. The participation of nitric oxide (NO) and sulfhydryl (SH) compounds was evaluated and the superoxide dismutase (SOD), gluthathione (GSH), catalase (CAT), malondialdehyde (MDA), prostaglandin E2 (PGE2) and NO level in the ethanol induced stomach tissue homogenate was determined. HPLC analysis confirmed the presence of quercetin and gallic acid in EAF. In pylorus-ligation model, EAF significantly (p <0.001) prevent gastric lesion formation. Volume of ...Continue Reading

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Citations

Nov 11, 2017·BMC Complementary and Alternative Medicine·Siti Zawanah HalimMuhammad Nazrul Hakim Abdullah
Nov 20, 2019·Drug and Chemical Toxicology·Muhammad Shah Zeb JanMuhammad Saeed Jan
Aug 5, 2020·Expert Opinion on Drug Discovery·Taraneh MousaviMohammad Abdollahi
Mar 25, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Young-Sik KimDonghun Lee
Jun 2, 2018·Oxidative Medicine and Cellular Longevity·Samara Alves BritoAlmir Gonçalves Wanderley
Dec 11, 2020·Chemico-biological Interactions·Meltem KolgaziGuldal Gulec Suyen
Apr 15, 2021·Journal of Ethnopharmacology·Mukta GuptaNaresh Singh

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Methods Mentioned

BETA
Assay
MDA
enzyme-linked immunosorbent assay

Software Mentioned

Xcalibur
Chameleon

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