Mechanisms of acute eosinophilic inflammation in a case of acute eosinophilic pneumonia in a 14-year-old girl

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
V GoddingW W Busse

Abstract

Acute eosinophilic pneumonia (AEP) is characterized by respiratory distress, eosinophilic infiltration in the lung, acute onset, resolution of symptoms with corticosteroids and the absence of relapse. Studies to identify the pathophysiology of AEP in adults have demonstrated eosinophil activation in the BAL fluid, and the presence of high levels of interleukin 5 (IL-5) in the BAL. To investigate the pathophysiology of AEP with pleural effusion in a paediatric patient. ECP levels in the BALand pleural fluid was determined by radioimmunoassay. IL-5 and GM-CSF concentrations in the BAL and pleural fluid were measured by Elisa. Immunohistochemistry studies performed on open lung biopsy included a specific ICAM-1 immunostaining and a ECP specific immunostaining (EG2+). High levels of ECP were found in the BAL (5 microg/L) and pleural fluid (750 microg/L) demonstrating eosinophil activation at these sites. Immunohistochemistry illustrated activated (EG2+) eosinophils in the interalveolar septa and alveolar space and detected increased expression of ICAM-1 on alveolar epithelial cells. High levels of IL-5 were measured in the BAL (1334 pg/mL) and pleural fluid (7014 pg/mL), while elevated concentrations of GM-CSF (150 pg/mL) were foun...Continue Reading

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Citations

May 2, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Laura DziadzioAnna Huttenlocher
Nov 30, 2002·Paediatric Respiratory Reviews·Jose Dirceu Ribeiro, Gilberto Bueno Fischer
Apr 17, 2009·Medicinski pregled·Ivana Meta-JevtovićMarina Petrović
Nov 6, 2015·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jee In SongHyeon-Jong Yang
Apr 12, 2007·Chest·Nawar Al-SaiegRitha Kartan
May 13, 2003·Chest·Catherine WubbelJames Sherman
Apr 22, 2004·Internal Medicine·Hiroshi OhnishiJitsuo Higaki
May 29, 2020·Journal of Investigative Medicine High Impact Case Reports·Prateek Suresh HarneZachary Shepherd

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