PMID: 7542333Mar 1, 1995Paper

Mechanisms of acylcarnitine-mediated enhancement of calcium transport in the Caco-2 cell monolayer model

Journal of Pharmaceutical Sciences
N SurendranJ Blanchard

Abstract

The overall objective of this study was to determine the mechanisms of acylcarnitine-mediated enhancement of calcium transport across Caco-2 cells. The different mechanisms of enhancement postulated are (a) loosening of tight junctions, thereby promoting paracellular transport; (b) opening of calcium channels, thus increasing calcium entry; and (c) stimulation of the basolateral Ca-ATPase pump, thereby aiding calcium extrusion. Although the existence of calcium channels and the reversal of verapamil-mediated inhibition of calcium uptake by acylcarnitines were demonstrated for the first time in Caco-2 cells, the channels do not appear to be a major contributing factor to the enhancement of calcium transport by acylcarnitines. Calmidazolium, a potent Ca-ATPase pump inhibitor in tissues such as rat intestinal segments, failed to inhibit this pump in Caco-2 cells. Thus, the predominant mechanism of enhancement of calcium transport by acylcarnitines in the Caco-2 model appears to be via promotion of paracellular transport.

Citations

Mar 5, 1999·Biological Trace Element Research·G Leblondel, P Allain
Aug 26, 1998·Annual Review of Nutrition·C J Rebouche, H Seim
Jun 21, 2016·Advanced Drug Delivery Reviews·Sam MaherDavid J Brayden
Mar 5, 1998·The American Journal of Physiology·M V ChirayathM Peterlik

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