PMID: 29782774Aug 1, 2016Paper

MECHANISMS OF AFOBAZOLE INFLUENCE ON THE NO PRODUCING ENDOTHELIUM FUNCTION AND INDICATORS OF OXIDATIVE STRESS IN RATS WITH EXPERIMENTAL DIABETES MELLITUS

Eksperimental'naia i klinicheskaia farmakologiia
S G DzugkoevN M Karchaidze

Abstract

Data on the mechanisms of afobazole effect on the NO-producing function of endothelium under conditions of oxidative stress in rats with experimental diabetes mellitus are presents. It is established for the first time that the drug in vivo inhibits the intensity of lipid peroxidation, reduces the concentration of malonic dialdehyde in red blood cells up to 16.07% (p = 0.05), increases superoxide dismutase activity by 13.6% (p = 0.05), and increases the total concentration of nitric oxide metabolites in blood serum by 33.3% (p = 0.001). The drug effect on NO-producing function of endothelium is due to the increased availability of L-arginine to NO-synthase (NOS-3), reduced level of atherogenesis risk factor (LDL cholesterol in serum), and increased expression of NOS-3 in vascular endothelium on the average by 30.5% (p = 0,001).

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.