Mechanisms of aging and development-A new understanding of environmental damage to the skin and prevention with topical antioxidants

Mechanisms of Ageing and Development
K E Burke

Abstract

Recent research has given us new insights into the molecular biology of extrinsic aging of the skin. Not only does UV irradiation directly cause photoaging of the skin, but also environmental pollutants significantly damage exposed skin by several mechanisms. Exposure to the noxious gases of air pollution with simultaneous exposure to UVA can act synergistically to initiate skin cancer. Also ozone generated from pollutants reacting with UV induces oxidative stress of the skin's surface via formation of lipid peroxidation products, with cascading consequences to deeper layers. Furthermore, new studies have demonstrated that particulate matter (PM) pollutants can penetrate the skin transepidermally and through hair follicles to induce skin aging via the aryl hydrocarbon receptor (AHR), a recently discovered ligand-activated transcription factor that regulates and protects keratinocytes, melanocytes, and fibroblasts. With this understanding that extrinsic aging of the skin is not only due to photoaging, we realize the necessity of protection beyond sunscreen. Fortunately, correctly formulated topical antioxidants can prevent damage inflicted by both UV and environmental pollution.

Citations

Sep 22, 2018·Clinical Pharmacology and Therapeutics·Karen E Burke
Dec 20, 2018·Molecular Ecology·Jessica L GrahamTimothy J Greives
Mar 22, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·E AraviiskaiaB Dreno
Jun 12, 2019·International Journal of Molecular Sciences·Georgeta BochevaAndrzej T Slominski
Feb 9, 2020·Pharmaceutics·Renata Spagolla Napoleão TavaresChristian Zoschke
May 10, 2020·Archives of Dermatological Research·Alessandra PecorelliDiane B Nelson
Jan 11, 2020·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Juergen LademannMaxim E Darvin
Dec 5, 2019·International Journal of Molecular Sciences·Christian VogeleyThomas Haarmann-Stemmann
Dec 21, 2018·International Journal of Molecular Medicine·Ping LiuTaek-Jeong Nam
Feb 6, 2019·International Journal of Molecular Sciences·Rosaria Di MauroGiovanni Li Volti
Jul 30, 2019·Frontiers in Pharmacology·Concepcion ParradoAngeles Juarranz
Jun 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Diana I S P ResendeMadalena M M Pinto
May 29, 2020·Environmental Science and Pollution Research International·Atif AliMuhammad Hassham Hassan Bin Asad
Jul 28, 2020·Particle and Fibre Toxicology·Irini M DijkhoffBarbara Rothen-Rutishauser
Feb 3, 2021·Dermatologic Therapy·Ruhollah AbolhasaniReza M Robati
Feb 5, 2021·International Journal of Women's Dermatology·Eva Rawlings Parker
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Vega Widya KarismaJulia Li Zhong
May 24, 2021·Advances in Colloid and Interface Science·Lucia SalvioniMiriam Colombo
Aug 28, 2021·International Journal of Molecular Sciences·Georgeta BochevaAndrzej T Slominski
Oct 23, 2021·International Journal of Cosmetic Science·Carine JacquesHélène Duplan

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