Mechanisms of airway hyperresponsiveness in asthma

Respirology : Official Journal of the Asian Pacific Society of Respirology
Norbert BerendG G King

Abstract

Airway hyperresponsiveness (AHR) is a fundamental abnormality in asthma. There are many potential factors contributing to the excessive airway response demonstrable on airway challenge. These range from abnormalities of airway smooth muscle, airway remodelling and airway inflammation to abnormalities in the neural control of airway calibre. None of these by themselves fully explains the abnormalities seen on the dose response curves of the asthmatic. In this review, the main mechanisms are described, together with recent evidence providing a pathway by which a number of these mechanisms may interact to cause AHR through abnormality in ventilation distribution and airway closure. There is now evidence for a close relationship between ventilation heterogeneity and AHR which could be exploited clinically.

References

Jan 1, 1992·Journal of Applied Physiology·H JiangN L Stephens
Jan 1, 1992·The Journal of Allergy and Clinical Immunology·D W CockcroftB P Gore
Mar 1, 1990·The American Review of Respiratory Disease·T R Bai
Jan 1, 1990·The American Review of Respiratory Disease·R J HoppN M Nair
Mar 11, 1989·Lancet·W R RocheS T Holgate
Dec 1, 1989·The American Review of Respiratory Disease·P K JefferyA B Kay
Jan 1, 1989·The American Review of Respiratory Disease·A L JamesJ C Hogg
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Mar 1, 1987·Journal of Applied Physiology·D J DingP T Macklem
Mar 1, 1969·Journal of Applied Physiology·K E Finucane, H J Colebatch
Aug 1, 1984·The Journal of Allergy and Clinical Immunology·R J HoppR G Townley
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·L BouletG Carrier
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·P PaolettiM Vellutini
Oct 1, 1993·The American Review of Respiratory Disease·B RijckenR Van der Lende
Nov 1, 1993·The American Review of Respiratory Disease·K KuwanoJ C Hogg
Jun 1, 1993·Journal of Applied Physiology·R K LambertP D Paré
Feb 1, 1993·The American Review of Respiratory Disease·N CarrollA James
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·P T Macklem
Sep 1, 1996·American Journal of Respiratory and Critical Care Medicine·R J ThomsonR R Schellenberg
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·N G CarrollA L James
Mar 1, 1997·Respiratory Medicine·D F JansenD S Postma
Jul 1, 1997·Journal of Applied Physiology·R K Lambert, P D Paré
Aug 1, 1997·American Journal of Respiratory Cell and Molecular Biology·J Solway, J J Fredberg
Oct 24, 1997·Journal of Applied Physiology·K R Lutchen, H Gillis
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·J J FredbergS A Shore
Jun 1, 1997·Respirology : Official Journal of the Asian Pacific Society of Respirology·A James, G Ryan
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·E CrimiV Brusasco
Oct 22, 1998·The New England Journal of Medicine·P LangeG Jensen
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·D S Postma, H A Kerstjens
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·G G KingA J Woolcock
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·C M SalomeA J Woolcock
Sep 18, 1999·The European Respiratory Journal·C LapriseL P Boulet

❮ Previous
Next ❯

Citations

Feb 5, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Richard Ruffin, Philip G Bardin
May 1, 2012·The Journal of Pharmacology and Experimental Therapeutics·Haihong JiangYaping Tu
Oct 26, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sharon R BullimoreAnne-Marie Lauzon
Jul 28, 2012·Journal of Applied Physiology·Catherine E FarrowGregory G King
Oct 22, 2008·American Journal of Respiratory Cell and Molecular Biology·Fabienne GallyAnne-Laure Perraud
Aug 24, 2013·Environmental Health Perspectives·Kathryn A RamseyGraeme R Zosky
Nov 12, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M YangP S Foster
Jun 19, 2012·The Journal of Allergy and Clinical Immunology·Yan XieYaping Tu
May 31, 2011·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Arndt MeierAllan Jones
Jan 25, 2011·Pulmonary Pharmacology & Therapeutics·Graham M Donovan
Jan 23, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C-C HsiehW-C Lin
Dec 17, 2009·European Journal of Pharmacology·Ahmed El-HashimHans-Uwe Simon
Jul 6, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·David A KaminskyDavid G Chapman
May 16, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·W Gerald TeagueTalissa A Altes
Mar 7, 2012·Journal of Immunotoxicology·David BasketterBeth Concoby
Nov 5, 2014·American Journal of Respiratory Cell and Molecular Biology·Haihong JiangYaping Tu
Mar 6, 2012·The Journal of Allergy and Clinical Immunology·Yafang TangDavid M Kemeny
Sep 25, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C NiuZ Fu
Jul 13, 2016·Immunology and Allergy Clinics of North America·Jacqueline O'TooleDavid A Kaminsky
Mar 20, 2015·PloS One·Valérie BougaultLouis-Philippe Boulet
May 17, 2018·The Cochrane Database of Systematic Reviews·Nitin KapurAnne B Chang
Oct 21, 2018·Chinese Journal of Integrative Medicine·Martha Perez Gutierrez Rosa, Maria Mota Flores Jose
Mar 7, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·David A KaminskyCharles G Irvin
Dec 7, 2010·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Geert K MoortgatPeter Warneck
Jul 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dan F SmelterY S Prakash
Jan 1, 2013·Current Protocols in Mouse Biology·François Daubeuf, Nelly Frossard
Sep 8, 2017·JCI Insight·Daniel P CookDavid A Stoltz
Oct 27, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Peng QiDianbo Kou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Journal of Allergy and Clinical Immunology
Donald W Cockcroft, Beth E Davis
Proceedings of the American Thoracic Society
Diana C Grootendorst, Klaus F Rabe
© 2022 Meta ULC. All rights reserved