Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries

British Journal of Pharmacology
R WhiteC Robin Hiley

Abstract

1. The cannabinoid arachidonyl ethanolamide (anandamide) caused concentration-dependent relaxation of 5-HT-precontracted, myograph-mounted, segments of rat left anterior descending coronary artery. 2. This relaxation was endothelium-independent, unaffected by the fatty acid amide hydrolase inhibitor, arachidonyl trifluoromethyl ketone (10 microM), and mimicked by the non-hydrolysable anandamide derivative, methanandamide. 3. Relaxations to anandamide were attenuated by the cannabinoid receptor antagonist, SR 141716A (3 microM), but unaffected by AM 251 (1 microM) and AM 630 (1 microM), more selective antagonists of cannabinoid CB(1) and CB(2) receptors respectively. Palmitoylethanolamide, a selective CB(2) receptor agonist, did not relax precontracted coronary arteries. 4. Anandamide relaxations were not affected by inhibition of sensory nerve transmission with capsaicin (10 microM) or blockade of vanilloid VR1 receptors with capsazepine (5 microM). Nevertheless capsaicin relaxed coronary arteries in a concentration-dependent and capsazepine-sensitive manner, confirming functional sensory nerves were present. In contrast, capsazepine and capsaicin did inhibit anandamide relaxations in methoxamine-precontracted rat small mesente...Continue Reading

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Citations

May 2, 2008·European Biophysics Journal : EBJ·Alison Gurney, Boris Manoury
Mar 15, 2012·Pflügers Archiv : European journal of physiology·Mélissa BolBert Vanheel
May 16, 2006·Cellular and Molecular Neurobiology·Angela Alsasua del Valle
Dec 31, 2002·Chemistry and Physics of Lipids·George KunosJudith Harvey-White
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