PMID: 2479208Jan 1, 1989Paper

Mechanisms of anesthesia-induced depression of myocardial function.

Acta anaesthesiologica Belgica
S De Hert, H Adriaensen

Abstract

Anesthetics may depress myocardial function. Part of this action is due to a direct negative inotropic effect of these agents. With the increasing knowledge on the cardiac excitation-contraction process, the understanding of the different possible mechanisms, underlying the anesthetic-induced myocardial depression also increases. The present state of knowledge on these possible mechanisms is reviewed and they are discussed as to their relative importance and their clinical relevance.

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