Mechanisms of augmented segment shortening in nonischemic areas during acute ischemia of the canine left ventricle

Circulation Research
W Y LewJ W Covell

Abstract

To examine the interaction between normal and nonischemic areas of the left ventricle during acute ischemia, we implanted midwall ultrasonic segment length gauges in the ischemic zone and in nonischemic areas of the canine left ventricle. During acute ischemia, end-diastolic pressure and segment length in the nonischemic areas increased. There was no change from control in the segment length at the time of aortic valve opening and closure. Thus, in nonischemic areas, total segment shortening, as measured by the percent change in segment length from the time of end-diastole to aortic valve closure, increased. This was due to an increase in isovolumic shortening (end-diastole to aortic valve opening) with no change in ejection shortening (aortic valve opening to closure). The progressive increase in isovolumic shortening in nonischemic areas over time was directly paralleled by the progressive development of the isovolumic lengthening or bulge in the ischemic zone. Nonischemic areas, whether adjacent, on the opposite wall, or distant to the ischemic zone, all behaved similarly. Adrenergic blockade did not qualitatively alter these findings. We conclude that acute ischemia induces a mechanical disadvantage which is greater than ju...Continue Reading

References

Jul 1, 1975·The American Journal of Cardiology·B C CoryaM J Black
Mar 4, 1976·The American Journal of Cardiology·H L WyattH J Swan
Jul 1, 1970·The Journal of Clinical Investigation·W B HoodR B Whiting
Mar 1, 1972·The American Journal of Physiology·S J LeshinJ H Mitchell
Sep 1, 1972·Cardiovascular Research·J HeikkiläP G Hugenholtz
Jan 1, 1983·The American Journal of Cardiology·M MolaugF Kiil
Jan 1, 1982·International Journal of Cardiology·O M HessJ Ross

Citations

Mar 1, 1992·Catheterization and Cardiovascular Diagnosis·J A GaschoW R Davidson
Jun 1, 1991·Pflügers Archiv : European journal of physiology·T Ehring, G Heusch
Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·V SchächingerA M Zeiher
Mar 1, 1989·Journal of the American College of Cardiology·S NomaR H Helfant
Nov 1, 1991·Journal of the American College of Cardiology·G JondeauC Eng
Nov 15, 1991·Journal of the American College of Cardiology·J A GoldsteinJ L Cox
Dec 1, 1994·Journal of the American College of Cardiology·T E MeyerP Foëx
Feb 15, 2005·Ultrasound in Medicine & Biology·J KuoO T von Ramm
Feb 5, 1998·Progress in Cardiovascular Diseases·J A Goldstein
Jun 25, 2003·International Journal of Cardiology·Silvana MüllerOtmar Pachinger
Sep 13, 2002·Journal of the American College of Cardiology·James A Goldstein
Oct 24, 2002·Journal of the American College of Cardiology·Cristina PislaruMarek Belohlavek
Jun 1, 1986·Journal of the American College of Cardiology·L D GillamA E Weyman
Oct 1, 1986·Journal of the American College of Cardiology·W S Weintraub, R H Helfant
Mar 15, 1997·Journal of the American College of Cardiology·S PerliniP Foëx
May 5, 2000·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·E DaherA J Sinusas
May 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·T MorozumiT Nishimura
Jul 28, 2001·Clinical and Experimental Pharmacology & Physiology·F DuJ Kedem
Mar 27, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Masahito MiuraChiyohiko Shindoh
Jun 24, 2004·The Tohoku Journal of Experimental Medicine·Yoshito YamamotoKunio Shirato
Sep 24, 2015·Journal of Cardiovascular Translational Research·William J Richardson, Jeffrey W Holmes
Jun 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·M ChinzeiK Numata
Feb 1, 1994·Journal of Cardiothoracic and Vascular Anesthesia·P Foëx, B J Leone
Jul 30, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Cristina PislaruJames F Greenleaf
Aug 1, 1995·Journal of Cardiothoracic and Vascular Anesthesia·K M VermeyenH F Adriaensen
Jan 14, 2004·Critical Care Nursing Clinics of North America·Sara Paul
Jun 29, 2004·Journal of Applied Physiology·Kevin Kit ParkerDavid E Hansen
Jan 6, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Erik LyseggenOtto A Smiseth
Nov 10, 2004·The Journal of Analytical Psychology·Richard Kradin
Jan 19, 2020·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M A van LavierenJ J Piek
Jul 1, 1991·Basic Research in Cardiology·M AkaishiY Nakamura
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Wenguang Li

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