Mechanisms of beauvericin toxicity and antioxidant cellular defense

Toxicology Letters
Beatriz MallebreraMaria-Jose Ruiz

Abstract

Beauvericin (BEA) is a secondary metabolite produced by many species of fungus Fusarium. This study determines the injury (cell viability, cell proliferation, mitochondrial membrane potential, cell death and DNA damage) and the intracellular defense mechanisms (catalase and superoxide dismutase) in Chinese Hamster ovary (CHO-K1) cells after BEA exposure. The results obtained in this study demonstrated that BEA induces cytotoxicity in a dose- and time-dependent manner in CHO-K1 cells. Moreover, disruption in mitochondrial enzymatic activity and cell proliferation has been observed after BEA exposure, which can lead or be consequence of cell death. BEA inhibits cell proliferation by arresting cells in G0/G1 and increasing apoptosis. Moreover, at higher exposure times, BEA induces differentiation of CHO-K1 cells through G2/M arrest, preventing that cells entry into mitosis. DNA strand breaks were observed at 1 μM after 24h of exposure. On the other hand, the SOD and CAT activities were increased after BEA exposure and as a defense system they could contribute to eliminate damage produced by BEA and oxidants products generated in CHO-K1 cells.

References

Nov 1, 1991·Experimental Cell Research·D M OjciusJ D Young
Jun 14, 2002·International Journal of Oncology·Darja KanducEmanuel Farber
Jan 25, 2003·Biochimica Et Biophysica Acta·K KouriR Lemmens-Gruber
Dec 14, 2005·Biochemical and Biophysical Research Communications·Bing-Fang ChenGuey-Mei Jow
Mar 1, 2007·Chemical Research in Toxicology·Rita DornetshuberRosa Lemmens-Gruber
Jun 12, 2009·Molecular Nutrition & Food Research·Rita DornetshuberWalter Berger
Jul 15, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E FerrerM J Ruiz
Aug 5, 2009·Molecular Nutrition & Food Research·Rita DornetshuberWalter Berger
Mar 17, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Giuseppe MecaJordi Mañes
May 10, 2011·Toxicon : Official Journal of the International Society on Toxinology·Diana DinuAnca Dinischiotu
Apr 10, 2012·Toxicology and Applied Pharmacology·A GammelsrudJ A Holme
Jul 3, 2013·Environmental Toxicology and Pharmacology·Jing WuLi-Xin Wen
Aug 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S MarinV Sanchis
Feb 18, 2014·Environmental Research·Silvia EspínAntonio J García-Fernández
Mar 13, 2014·Toxicology Letters·B MallebreraM J Ruiz
Jul 30, 2014·Toxicology Letters·Celia Fernández-BlancoMaria-Jose Ruiz
Apr 7, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B MallebreraM J Ruiz

❮ Previous
Next ❯

Citations

May 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Davide FerrigoRoberto Causin
Jul 29, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Elena TatayMaria-Jose Ruiz
Jan 24, 2018·Technology in Cancer Research & Treatment·Li LiaoGu-Qing Zeng
Aug 15, 2019·Molecular Reproduction and Development·Antonella MastroroccoFiorenza Minervini
Jan 12, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Mandakini S KshirsagarArun Patil
Jan 25, 2020·International Journal of Environmental Research and Public Health·Giuseppe GenchiAlessia Catalano
Mar 29, 2020·International Journal of Environmental Research and Public Health·Amit KumarKrishna K Yadav
May 30, 2020·International Journal of Environmental Research and Public Health·Giuseppe GenchiAlessia Catalano
Jan 14, 2017·International Journal of Environmental Research and Public Health·Giuseppe GenchiAlessia Catalano
Dec 6, 2018·Frontiers in Pharmacology·Qinghua WuKamil Kuca
Jun 20, 2018·Toxins·Alessia BerteroFrancesca Caloni
Apr 21, 2020·Toxicology Mechanisms and Methods·Mercedes TaroncherMaria-Jose Ruiz
Nov 4, 2020·Toxins·Alessia BerteroFrancesca Caloni
May 11, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Domenico MontesanoCristina Juan
May 28, 2021·Toxicology Mechanisms and Methods·Veronica ZingalesMaria-José Ruiz
May 10, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Elena TatayMaría-José Ruiz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis