Mechanisms of bone erosion in gout: a quantitative analysis using plain radiography and computed tomography

Annals of the Rheumatic Diseases
N DalbethFiona M McQueen

Abstract

The underlying basis of bone erosion in gout remains speculative. The aim of this study was to understand the mechanisms of bone erosion in gout using non-invasive imaging techniques. Paired plain radiographs and computed tomography (CT) scans of 798 individual hand and wrist joints from 20 patients with gout were analysed. Radiographs were scored for erosion (0-5) using the Sharp/van der Heijde method. CT scans were scored for the presence and diameter of bone erosions and tophi. The presence of intraosseous tophus (tophus visualised within bone) was recorded. The relationships between radiographic erosion, CT erosion and tophus scores were analysed. With increasing radiographic erosion scores, the percentage of joints with intraosseous tophus increased (p<0.001). For those joints with a radiographic erosion score of 4 or 5, 96/98 (98%) had CT evidence of intraosseous tophus. There was a significant relationship between the radiographic erosion scores and intraosseous tophus size (p<0.001). For those joints with CT erosion, 194/237 (81.8%) had visible intraosseous tophus. Of the joints with CT erosions greater than 5 mm, 106/112 (94.6%) had visible intraosseous tophus and all (56/56) erosions greater than 7.5 mm had intraosseo...Continue Reading

Citations

Jan 22, 2013·Annals of the Rheumatic Diseases·Nicola DalbethFiona M McQueen
Dec 24, 2013·BMC Musculoskeletal Disorders·Nicola DalbethWilliam J Taylor
Dec 22, 2012·Arthritis Research & Therapy·Tim L Jansen
Aug 27, 2013·AJR. American Journal of Roentgenology·Gandikota GirishJon A Jacobson
Nov 28, 2013·Nature Reviews. Rheumatology·Fiona M McQueen
Apr 16, 2013·Arthritis·Gandikota GirishDavid A Jamadar
Jan 8, 2013·Current Rheumatology Reports·Nicola Dalbeth, Hyon K Choi
Dec 4, 2015·Journal of Medical Imaging and Radiation Oncology·Anthony J DoyleMike Frecklington
Oct 7, 2015·Journal of Medical Imaging and Radiation Oncology·Nishanthinie ParathithasanWarren Perera
Apr 8, 2014·Rheumatic Diseases Clinics of North America·Ashika Chhana, Nicola Dalbeth
Apr 8, 2014·Rheumatic Diseases Clinics of North America·Fiona M McQueenNicola Dalbeth
Jan 1, 2013·Best Practice & Research. Clinical Rheumatology·Fiona M McQueen, Mikkel Ostergaard
Jan 1, 2013·Best Practice & Research. Clinical Rheumatology·Nicola Dalbeth, Anthony J Doyle
Mar 6, 2012·Joint, Bone, Spine : Revue Du Rhumatisme·Sébastien OttavianiPascal Richette
Jan 10, 2012·Reumatología clinica·Cristóbal M Rodríguez LealFrancisco Javier Quirós
May 18, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Tony R Merriman, Nicola Dalbeth
Aug 21, 2009·Lancet·Pascal Richette, Thomas Bardin
Feb 5, 2010·Arthritis and Rheumatism·Nicola DalbethJillian Cornish
Nov 3, 2015·Seminars in Arthritis and Rheumatism·Laura DurcanNicola Dalbeth
Nov 13, 2015·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mihra S TaljanovicAndrea S Klauser
Feb 1, 2015·Annals of the Rheumatic Diseases·Nicola DalbethFiona M McQueen
Jan 22, 2014·Annals of the Rheumatic Diseases·Ahmed S ZayatRichard J Wakefield
Dec 24, 2014·Advances in Therapy·Fernando Perez-RuizTomas Bardin
Oct 30, 2016·Lancet·Nicola DalbethLisa K Stamp
Aug 16, 2016·International Journal of Rheumatic Diseases·Young Sun SuhHyun-Ok Kim
Aug 15, 2014·Indian Journal of Pathology & Microbiology·Reena TomarVinod Kumar Arora
Feb 26, 2016·Annals of the Rheumatic Diseases·Alastair EasonNicola Dalbeth
Oct 1, 2011·Journal of the American Podiatric Medical Association·Keith RomePeter J McNair
Feb 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siti Sarwani Putri Mohamed IsaJamaludin Mohamad
Oct 5, 2017·Arthritis & Rheumatology·Nicola DalbethLhanoo Gunawardhana

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