Mechanisms of Botulinum Toxin Type A Action on Pain

Toxins
Ivica MatakZsuzsanna Helyes

Abstract

Already a well-established treatment for different autonomic and movement disorders, the use of botulinum toxin type A (BoNT/A) in pain conditions is now continuously expanding. Currently, the only approved use of BoNT/A in relation to pain is the treatment of chronic migraines. However, controlled clinical studies show promising results in neuropathic and other chronic pain disorders. In comparison with other conventional and non-conventional analgesic drugs, the greatest advantages of BoNT/A use are its sustained effect after a single application and its safety. Its efficacy in certain therapy-resistant pain conditions is of special importance. Novel results in recent years has led to a better understanding of its actions, although further experimental and clinical research is warranted. Here, we summarize the effects contributing to these advantageous properties of BoNT/A in pain therapy, specific actions along the nociceptive pathway, consequences of its central activities, the molecular mechanisms of actions in neurons, and general pharmacokinetic parameters.

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Citations

Jan 18, 2020·Toxins·Shivam Om Mittal, Bahman Jabbari
Sep 1, 2020·Journal of Cosmetic Dermatology·Mark S NestorDaniel L Fischer
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Jul 19, 2021·Toxicon : Official Journal of the International Society on Toxinology·Andrey GrishinLyailya Kayumova

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Methods Mentioned

BETA
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