Mechanisms of CaMKII action in long-term potentiation.

Nature Reviews. Neuroscience
John LismanSridhar Raghavachari

Abstract

Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for long periods, making it a probable mechanism for memory storage. LTP induction results in calcium entry, which activates calcium/calmodulin-dependent protein kinase II (CaMKII). CaMKII subsequently translocates to the synapse, where it binds to NMDA-type glutamate receptors and produces potentiation by phosphorylating principal and auxiliary subunits of AMPA-type glutamate receptors. These processes are all localized to stimulated spines and account for the synapse-specificity of LTP. In the later stages of LTP, CaMKII has a structural role in enlarging and strengthening the synapse.

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Citations

Jun 5, 2013·Behavioural Brain Research·Alanna C EastonChristian P Müller
Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Balakrishnan SelvakumarSolomon H Snyder
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