Mechanisms of cardiac preconditioning: ten years after the discovery of ischemic preconditioning

The Journal of Surgical Research
D R Meldrum

Abstract

Cardiac preconditioning describes the phenomenon by which transient ischemia induces myocardial protection against subsequent ischemia and reperfusion injury. Ten years have passed since the original description of this potent cardiac protective strategy and within this period tremendous progress has been made elucidating the mechanisms of preconditioning. Mechanistic understanding may allow safe clinical application. This review (1) recalls the history of preconditioning and how it relates to the history of the investigation of endogenous adaptation; (2) summarizes the current mechanistic understanding of early preconditioning; (3) compares and contrasts the mechanisms of early versus delayed preconditioning; (4) suggests potential anti-inflammatory aspects of preconditioning; (5) examines limitations in laboratory models of preconditioning; and (6) explores the potential of using preconditioning clinically.

References

Feb 1, 1992·Circulation Research·G J Gross, J A Auchampach
Jan 1, 1992·The Journal of Surgical Research·R S PoggettiA Banerjee
May 1, 1992·Journal of Molecular and Cellular Cardiology·J M BrownA H Harken
Aug 1, 1990·Annals of Surgery·J M BrownJ B Sharefkin
Jan 1, 1990·Journal of Molecular and Cellular Cardiology·R D LasleyR M Mentzer
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J M BrownJ E Repine
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J M BrownJ E Repine
Oct 1, 1995·The American Journal of Physiology·N MaulikD K Das
Apr 1, 1995·Journal of Molecular and Cellular Cardiology·D M Yellon, G F Baxter
Nov 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S L LiuM A Zern
Nov 10, 1995·The Journal of Biological Chemistry·K N SchmidtP A Baeuerle
Sep 1, 1995·The Annals of Thoracic Surgery·R T RowlandJ M Brown
Apr 1, 1995·The Journal of Clinical Investigation·J C PlumierG N Pagoulatos
Feb 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S MihmW Dröge
Nov 1, 1994·International Journal of Immunopharmacology·H M ShenD W Ou
Nov 30, 1994·Experientia·T J Hall
Jan 1, 1995·Circulation Research·M B MitchellA Banerjee
Jul 31, 1993·Lancet·D M YellonW B Pugsley
Sep 1, 1993·Basic Research in Cardiology·C SteenbergenE Murphy

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Citations

Jun 1, 2006·Biochemical and Biophysical Research Communications·Kaori Shintani-IshidaKen-ichi Yoshida
Feb 4, 2016·Clinical Transplantation·Prashant N MohiteAndre R Simon
Jun 16, 1999·Nitric Oxide : Biology and Chemistry·I Y MalyshevA F Vanin
Jan 27, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R I GasparriD E Van Raemdonck
Jan 15, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Matti R Tarkka
Jun 7, 2005·The Journal of Surgical Research·Jeffrey M PitcherDaniel R Meldrum
Jul 13, 2000·Critical Care Medicine·B S Cain, T C Tung
Jul 23, 2008·American Journal of Therapeutics·Patricio López-JaramilloVictor Castillo
May 3, 2006·Cerebrovascular Diseases·Miguel BlancoJosé Castillo
Apr 15, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Qilin YuJohn A Johnson
Nov 21, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Naz ChaudaryImogen R Coe
Mar 11, 2000·American Journal of Physiology. Renal Physiology·H T Lee, C W Emala
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M XuM Ashraf
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Thorsten Reffelmann, Robert A Kloner
May 15, 2003·Trends in Neurosciences·Ulrich DirnaglJohn M Hallenbeck

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