Mechanisms of cardiovascular dysregulation during alcohol withdrawal

Progress in Neuro-psychopharmacology & Biological Psychiatry
Seppo Kähkönen

Abstract

Alcohol withdrawal (AW) is often accompanied by functional cardiovascular abnormalities which return to normal in few days. However, in some patients, they can predict future alterations in the cardiovascular system, even if they remain in abstinence. These changes are mediated by several central and peripheral mechanisms closely related to AW. The level of activation in the sympathetic nervous system is an important factor regulating the functioning of the cardiovascular system in AW directly and/or indirectly with L-type calcium channels and nitric oxide (NO). Other factors may contribute to cardiovascular alterations in AW including the renin-angiotensin-aldosterone system, vasopressin, cortisol and sodium sensitivity. Monitoring of the cardiovascular system is needed in patients undergoing treatment for AW. The patients with elevated systolic blood pressure (SBP) and diastolic blood pressure (DBP) after resolution of AW may require a fuller work-up of their cardiovascular system.

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Citations

Jul 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Young-Chang P AraiYuki Maruyama
Jan 23, 2016·Drug and Alcohol Dependence·Thomas JochumKarl-Jürgen Bär
Nov 8, 2011·Drug and Alcohol Dependence·Thomas JochumKarl-Jürgen Bär
May 12, 2010·Drug and Alcohol Dependence·Thomas JochumKarl-Jürgen Bär
Mar 12, 2016·Neuroscience·Jason H WelchC Fernando Valenzuela
Feb 13, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seppo KähkönenZvartau Edwin
Aug 26, 2006·Alcoholism, Clinical and Experimental Research·Karl-Jürgen BärAndreas Voss
May 3, 2006·Drug and Alcohol Dependence·Karl-Jürgen BärAndreas Voss
Jul 2, 2011·Drug and Alcohol Dependence·Thomas JochumKarl-Jürgen Bär
May 15, 2013·Drug and Alcohol Dependence·Marco HerbslebKarl-Jürgen Bär
Dec 28, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seppo KähkönenBoris Bondarenko
Nov 2, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Seppo Kähkönen

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