PMID: 3756111Sep 1, 1986Paper

Mechanisms of cardiovascular regulation in male rabbits chronically exposed to cadmium

British Journal of Industrial Medicine
P Boscolo, M Carmignani

Abstract

Male rabbits received 20 micrograms/ml of cadmium in drinking water for nine months. At the end of the treatment aortic vascular resistance was increased, whereas maximum rate of increase in left ventricular pressure, aortic blood flow, stroke volume, cardiac output, left ventricular minute work, and left ventricular stroke work were reduced. Arterial blood pressure, heart rate, and the index of myocardial oxygen consumption were not modified. The exposed rabbits also showed reduced pressor responses to vagotomy, increased cardiovascular responses to angiotensin I and II and isoprenaline, and lower responses to serotonin and guanethidine; the bradycardia induced by clonidine was augmented; the cardiovascular effects of bilateral carotid occlusion, hexamethonium, phenylephrine, histamine, acetylcholine, tyramine, papaverine and verapamil were unaltered. In the treated rabbits cadmium was appreciably higher in the kidney than in the heart; however, renal concentrations of cadmium were lower than those reported as critical for workers exposed to cadmium. Zinc was increased in the kidney but not in the heart, whereas copper remained unchanged in the examined organs. In rabbits treated with cadmium the increased aortic vascular resi...Continue Reading

References

Jul 3, 1978·Life Sciences·M G Cherian, R A Goyer
Dec 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·S J KoppH M Perry
Jul 1, 1976·Journal of Agricultural and Food Chemistry·L Murthy, H G Petering
Aug 1, 1972·European Journal of Pharmacology·W Kobinger, A Walland
May 1, 1974·Cardiovascular Research·D M DavidsonJ Ross
Nov 1, 1970·Archives of Environmental Health·M Piscator, B Axelsson
Oct 31, 1983·Biochemical and Biophysical Research Communications·F RenduS Levy-Toledano
Sep 15, 1984·Toxicology and Applied Pharmacology·R C PrenticeS J Kopp
Jul 1, 1983·British Journal of Pharmacology·T Nasu
Mar 1, 1983·Toxicology Letters·H RoelsA N Dardenne
Jan 1, 1981·Toxicology Letters·P BoscoloV N Finelli
Apr 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·C F PilatiN F Paradise
Oct 1, 1981·British Journal of Pharmacology·T ItohH Kuriyama

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Citations

Jan 1, 2004·Toxicology Mechanisms and Methods·Wojciech KosmalaJolanta Antonowicz-Juchniewicz
Sep 26, 2009·Toxicology Mechanisms and Methods·Ikbal M OzturkSemra Erdogan

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