PMID: 18421981Apr 22, 2008Paper

Mechanisms of cerebral cortical development

Brain and nerve = Shinkei kenkyū no shinpo
Kazuma Kobayashi, Kazunori Nakajima

Abstract

The development of cerebral cortex is regulated by complex mechanisms. Various classes of neurons migrate from the proliferative zones to the cortex according to a spatiotemporal manner. There are two distinct modes of neuronal migration: radial migration and tangential migration. In the benefit of the advancement of research techniques such as in utero electroporation and time-lapse observation of living tissues, more aspects of the cell and molecular mechanisms that control these two migration modes and their roles in the cortical development have been clarified.

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