PMID: 9546034Apr 18, 1998Paper

Mechanisms of cerebral injury in perinatal asphyxia and strategies for prevention

The Journal of Pediatrics
M Delivoria-Papadopoulos, O P Mishra

Abstract

We have investigated the mechanisms of hypoxic brain cell injury in the immature animal by examining (1) the role of excitatory amino acid neurotransmitter receptors, (2) the receptor-mediated increase in intracellular Ca2+, and (3) the generation of oxygen free radicals. We examined the effect of brain tissue hypoxia on the NMDA receptor-ion channel complex including the glutamate, Mg2+, spermine, CPP, and the non-NMDA receptor kainate sites. Brain tissue hypoxia resulted in modification of the NMDA receptor ion channel and its modulatory sites. Hypoxia increased the affinity of both the ion channel and the glutamate recognition site. Pretreatment of animals with the glutamate antagonist CPP prevented hypoxia-induced modification of the channel. Similarly, pretreatment of animals with Mg2+, a blocker of the NMDA receptor ion channel, prevented the hypoxia-induced modification of the receptor. In addition, an increased agonist-dependent entry of Ca2+ into synaptosomes was observed in hypoxic animals compared with normoxic animals. Increased free radical generation in the cerebral cortex during hypoxia was demonstrated using spin labeling technique and electron spin resonance spectroscopy. We conclude that hypoxia-induced modifi...Continue Reading

References

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Citations

Nov 30, 2000·Current Treatment Options in Neurology·M V Johnston
Oct 25, 2001·Brain Research. Developmental Brain Research·M D WeissK J Anderson
Jul 12, 2003·Brain Research. Developmental Brain Research·Michael D WeissKevin J Anderson
May 6, 1999·Brain Research Bulletin·O P Mishra, M Delivoria-Papadopoulos
Nov 25, 2006·Developmental Neuroscience·Avital LeiboviciMichael D Weiss
Jul 28, 2004·Anesthesiology·Kanwaljeet J S Anand, Sulpicio G Soriano
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·M V Johnston
Apr 19, 2008·Brain Research·Didem Cemile YesilirmakHasan Ozkan
Dec 7, 2006·Clinics in Perinatology·Saraid S BilliardsHannah C Kinney
Mar 20, 1999·Brain Research·E SpandouO Guiba-Tziampiri
Apr 21, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ayse SolarogluHulya Dede
Mar 23, 2001·American Journal of Obstetrics and Gynecology·E M GrahamM Delivoria-Papadopoulos
May 10, 2000·Seminars in Neonatology : SN·M V JohnstonW Nakajima
Apr 15, 2006·Journal of Korean Medical Science·Won Soon ParkMunhyang Lee
Jun 17, 2006·Journal of Korean Medical Science·Won Soon ParkMunhyang Lee
Apr 4, 2006·Biology of the Neonate·Rodolfo BracciGiuseppe Buonocore
Mar 2, 2012·Neuroendocrinology·S L MillerD W Walker
Oct 6, 2005·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Vincenzo FodaleLetterio B Santamaria
Jun 1, 2001·Pediatric Research·M V JohnstonW Nakajima
Jul 31, 2001·Pediatric Research·G Ceresoli-Borroni, R Schwarcz
Sep 19, 2019·Revista da Associação Médica Brasileira·Mahara NonatoMirto Prandini
Jun 5, 2001·Current Opinion in Pediatrics·H Kirpalani, E Asztalos
Aug 9, 2003·Pediatric Research·Pasquale FlorioGiuseppe Buonocore
May 20, 2000·Annals of the New York Academy of Sciences·M Delivoria-Papadopoulos, O P Mishra
Oct 25, 2003·Journal of Neuropathology and Experimental Neurology·Rita Machaalani, Karen A Waters

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