Mechanisms of Desiccation Tolerance: Themes and Variations in Brine Shrimp, Roundworms, and Tardigrades

Frontiers in Physiology
Jonathan D HibshmanBob Goldstein

Abstract

Water is critical for the survival of most cells and organisms. Remarkably, a small number of multicellular animals are able to survive nearly complete drying. The phenomenon of anhydrobiosis, or life without water, has been of interest to researchers for over 300 years. In this review we discuss advances in our understanding of protectants and mechanisms of desiccation tolerance that have emerged from research in three anhydrobiotic invertebrates: brine shrimp (Artemia), roundworms (nematodes), and tardigrades (water bears). Discovery of molecular protectants that allow each of these three animals to survive drying diversifies our understanding of desiccation tolerance, and convergent themes suggest mechanisms that may offer a general model for engineering desiccation tolerance in other contexts.

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Citations

Dec 30, 2020·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Nadja Møbjerg, Ricardo Cardoso Neves
Apr 3, 2021·Frontiers in Zoology·Daria WojciechowskaHanna Kmita
Jun 3, 2021·International Journal of Molecular Sciences·Shoko TokumotoTakahiro Kikawada
Aug 5, 2021·Environmental Microbiology·Jason BoschDon A Cowan
Nov 6, 2021·Scientific Reports·Maho Yagi-UtsumiKoichi Kato

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Methods Mentioned

BETA
targeted mutations
protein folding
gene knockdown
X-ray

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