Mechanisms of doxorubicin-induced drug resistance and drug resistant tumour growth in a murine breast tumour model

BMC Cancer
Claudia ChristowitzAnna-Mart Engelbrecht

Abstract

Doxorubicin is currently the most effective chemotherapeutic drug used to treat breast cancer. It has, however, been shown that doxorubicin can induce drug resistance resulting in poor patient prognosis and survival. Studies reported that the interaction between signalling pathways can promote drug resistance through the induction of proliferation, cell cycle progression and prevention of apoptosis. The aim of this study was therefore to determine the effects of doxorubicin on apoptosis signalling, autophagy, the mitogen-activated protein kinase (MAPK)- and phosphoinositide 3-kinase (PI3K)/Akt signalling pathway, cell cycle control, and regulators of the epithelial-mesenchymal transition (EMT) process in murine breast cancer tumours. A tumour-bearing mouse model was established by injecting murine E0771 breast cancer cells, suspended in Hank's Balances Salt Solution and Corning® Matrigel® Basement Membrane Matrix, into female C57BL/6 mice. Fourty-seven mice were randomly divided into three groups, namely tumour control (received Hank's Balances Salt Solution), low dose doxorubicin (received total of 6 mg/ml doxorubicin) and high dose doxorubicin (received total of 15 mg/ml doxorubicin) groups. A higher tumour growth rate was, h...Continue Reading

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Citations

Sep 5, 2020·Cancers·Samson Mathews SamuelDietrich Büsselberg
Aug 18, 2020·Molecular Cancer·Tianwei XuZhaoxia Wang
Mar 4, 2020·International Journal of Molecular Sciences·Maxim E MenyailoEvgeny V Denisov
Nov 15, 2020·Journal of Experimental & Clinical Cancer Research : CR·Cristina Alexandra Ciocan-CartitaCornelia Braicu
Jul 6, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marieke OlsmanCatharina de Lange Davies
Apr 1, 2021·Journal of Drug Targeting·Mohammad TaheriSoudeh Ghafouri-Fard
Apr 13, 2021·Journal of Photochemistry and Photobiology. B, Biology·Ágata Silva CabralMarilia Freitas Calmon
Jul 3, 2021·Pharmaceutics·Binita ShresthaLiang Tang
Jul 17, 2021·European Journal of Pharmacology·Sepideh MirzaeiSaeed Samarghandian
Jul 25, 2021·Cancers·Anna WawruszakAndrzej Stepulak
Aug 28, 2021·International Journal of Molecular Sciences·Alessia SalzilloLuigi Sapio
Sep 12, 2020·Recent Patents on Anti-cancer Drug Discovery·Arunaksharan Narayanankutty
Nov 17, 2021·Journal of Biochemical and Molecular Toxicology·Shengcui LiuRuikui Zhang

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Methods Mentioned

BETA
RSA
Fluorescence

Software Mentioned

GraphPad Prism
Image J
Rad Image [UNK]
Bio

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