PMID: 3754411Mar 1, 1986Paper

Mechanisms of electrically induced damage after cochlear implantation

The Annals of Otology, Rhinology, and Laryngology
L G Duckert, J M Miller

Abstract

This report is the fourth in a series of parametric studies designed to evaluate and define conditions that may produce histological damage by means of electrical stimulation from cochlear prostheses. Earlier studies established damage thresholds for both acute (400 microA rms or 70 microC/cm(2)0) and chronic (100 microA rms or 15 to 20 microC/cm(2)0) stimulation with continuous sinusoidal current of 1,000 Hz. In a subsequent study, a tenfold reduction in the stimulation frequency (to 100 Hz) resulted in a 50% reduction in the acute damage threshold (200 microA rms), which was a smaller reduction than anticipated if damage is dependent only on charge density. This finding and the damage patterns observed in the preceding studies suggested that multiple mechanisms are responsible for the sensory and supporting cell degeneration induced by the electrical stimulus. A similar pattern of structural changes has been observed by other investigators after acoustic stimulation of the cochlea, suggesting that common mechanisms may be involved. With electrical stimulation, electrophoretic effects have been implicated; like acoustic trauma, however, mechanical, biochemical, and metabolic processes may also be involved. This investigation w...Continue Reading

Citations

Nov 1, 1987·IEEE Transactions on Bio-medical Engineering·J T RubinsteinM F Suesserman
Nov 20, 2002·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Dong X NongYutaka Noda
Aug 10, 2002·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Bülent SatarYalçin Ozkaptan

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