Abstract
Intervertebral disc (IVD) degeneration is frequently associated with Low back pain (LBP), which can severely reduce the quality of human life and cause enormous economic loss. However, there is a lack of long-lasting and effective therapies for IVD degeneration at present. Recently, stem cell based tissue engineering techniques have provided novel and promising treatment for the repair of degenerative IVDs. Numerous studies showed that stem/progenitor cells exist naturally in IVDs and could migrate from their niche to the IVD to maintain the quantity of nucleus pulposus (NP) cells. Unfortunately, these endogenous repair processes cannot prevent IVD degeneration as effectively as expected. Therefore, theoretical basis for regeneration of the NP in situ can be obtained from studying the mechanisms of endogenous repair failure during IVD degeneration. Although there have been few researches to study the mechanism of cell death and migration of stem/progenitor cells in IVD so far, studies demonstrated that the major inducing factors (compression and hypoxia) of IVD degeneration could decrease the number of NP cells by regulating apoptosis, autophagy, and necroptosis, and the particular chemokines and their receptors played a vital ...Continue Reading
Citations
Aug 18, 2020·Stem Cells and Development·Zhe WangZengwu Shao
Mar 19, 2020·Oxidative Medicine and Cellular Longevity·Sheng ChenZengwu Shao
Jun 27, 2020·Medicine·Mengmeng ChenRuideng Wang
Apr 23, 2020·Aging·Zhibiao BaiZhenming Hu
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Yiqiang HuLiming Xiong
Mar 21, 2020·Frontiers in Cell and Developmental Biology·Sheng ChenHuiling Cao
Jun 27, 2020·Stem Cells International·Gianluca VadalàVincenzo Denaro
Jan 30, 2020·Journal of Orthopaedic Surgery and Research·DaSheng TianJuehua Jing
May 21, 2020·Journal of Korean Neurosurgical Society·Hyung-Ki ParkJae-Chil Chang
Nov 13, 2020·Lasers in Medical Science·Igor BorshchenkoMaria Borshchenko
Jan 19, 2021·Autophagy·Ruijun HeZengwu Shao
Dec 12, 2020·Diagnostics·Shangbin CuiSibylle Grad
Feb 9, 2021·Frontiers in Bioengineering and Biotechnology·Yanbin ZhangLiming Xiong
Jan 29, 2021·World Journal of Stem Cells·Li-Ping NanLiang Zhang
Nov 22, 2020·International Journal of Molecular Sciences·Hitoshi TonomuraKenji Takahashi
Feb 26, 2021·Life Sciences·Chao-Yang Gong, Hai-Hong Zhang
Mar 8, 2021·Biochemical and Biophysical Research Communications·Wang DingXiaofan Yin
Mar 12, 2021·Journal of Food Biochemistry·Chinnarasu Marimuthu, Vedham Pushpa Rani
Oct 3, 2020·Osteoarthritis and Cartilage·Shuo ZhangZengwu Shao
Apr 4, 2021·International Journal of Molecular Sciences·Andreas S CroftBenjamin Gantenbein
Jun 10, 2021·BioMed Research International·Haiwei XuBaoshan Xu
Jul 27, 2021·Bioengineered·Ming LeiCao Yang
Jul 24, 2021·Advanced Healthcare Materials·Tyler J DiStefanoJames C Iatridis
Jul 27, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Yidian WangXuewen Kang
Aug 10, 2021·Stem Cells International·Yuxiang DuLingli Zhang
May 26, 2020·Biomaterials·Leslie FrapinCatherine Le Visage