Mechanisms of endogenous repair failure during intervertebral disc degeneration

Osteoarthritis and Cartilage
K MaZ Shao

Abstract

Intervertebral disc (IVD) degeneration is frequently associated with Low back pain (LBP), which can severely reduce the quality of human life and cause enormous economic loss. However, there is a lack of long-lasting and effective therapies for IVD degeneration at present. Recently, stem cell based tissue engineering techniques have provided novel and promising treatment for the repair of degenerative IVDs. Numerous studies showed that stem/progenitor cells exist naturally in IVDs and could migrate from their niche to the IVD to maintain the quantity of nucleus pulposus (NP) cells. Unfortunately, these endogenous repair processes cannot prevent IVD degeneration as effectively as expected. Therefore, theoretical basis for regeneration of the NP in situ can be obtained from studying the mechanisms of endogenous repair failure during IVD degeneration. Although there have been few researches to study the mechanism of cell death and migration of stem/progenitor cells in IVD so far, studies demonstrated that the major inducing factors (compression and hypoxia) of IVD degeneration could decrease the number of NP cells by regulating apoptosis, autophagy, and necroptosis, and the particular chemokines and their receptors played a vital ...Continue Reading

Citations

Feb 9, 2021·Frontiers in Bioengineering and Biotechnology·Yanbin ZhangLiming Xiong
Nov 22, 2020·International Journal of Molecular Sciences·Hitoshi TonomuraKenji Takahashi
Feb 26, 2021·Life Sciences·Chao-Yang Gong, Hai-Hong Zhang
Mar 8, 2021·Biochemical and Biophysical Research Communications·Wang DingXiaofan Yin
Apr 4, 2021·International Journal of Molecular Sciences·Andreas S CroftBenjamin Gantenbein
Jul 27, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Yidian WangXuewen Kang

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