Mechanisms of endothelial dysfunction in resistance arteries from patients with end-stage renal disease.

PloS One
Leanid LukshaKarolina Kublickiene

Abstract

The study focuses on the mechanisms of endothelial dysfunction in the uremic milieu. Subcutaneous resistance arteries from 35 end-stage renal disease (ESRD) patients and 28 matched controls were studied ex-vivo. Basal and receptor-dependent effects of endothelium-derived factors, expression of endothelial NO synthase (eNOS), prerequisites for myoendothelial gap junctions (MEGJ), and associations between endothelium-dependent responses and plasma levels of endothelial dysfunction markers were assessed. The contribution of endothelium-derived hyperpolarizing factor (EDHF) to endothelium-dependent relaxation was impaired in uremic arteries after stimulation with bradykinin, but not acetylcholine, reflecting the agonist-specific differences. Diminished vasodilator influences of the endothelium on basal tone and enhanced plasma levels of asymmetrical dimethyl L-arginine (ADMA) suggest impairment in NO-mediated regulation of uremic arteries. eNOS expression and contribution of MEGJs to EDHF type responses were unaltered. Plasma levels of ADMA were negatively associated with endothelium-dependent responses in uremic arteries. Preserved responses of smooth muscle to pinacidil and NO-donor indicate alterations within the endothelium and...Continue Reading

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Citations

May 29, 2014·Current Opinion in Nephrology and Hypertension·Ming Chang HuOrson W Moe
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Jan 7, 2021·Toxins·Nikolaos C KyriakidisPeter Stenvinkel

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Methods Mentioned

BETA
biopsies
ELISA

Software Mentioned

STATISTICA

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