PMID: 9527536Apr 4, 1998Paper

Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion

The Journal of Comparative Neurology
K L LankfordJ D Kocsis

Abstract

To examine the mechanisms responsible for the more rapid nerve regeneration observed after a previous (conditioning) nerve injury, adult rats were subjected to a midthigh sciatic nerve transection by using one of three protocols designed to facilitate or restrict nerve regeneration: 1) ligation, in which transected axons were prevented from regenerating; 2) cut, in which transected axons were permitted to extend into peripheral target tissue but were separated from the denervated peripheral nerve stump; and 3) crush, in which axons could regenerate normally through the denervated distal nerve tract. The affected dorsal root ganglia (DRG) were subsequently removed, dissociated, and cultured for up to 3 days, and the timing of neurite initiation, rate of outgrowth, and arborization pattern of previously injured neurons were compared with control DRG. Our results indicate that conditioning lesions have at least four distinct and differentially regulated effects on neuronal morphogenesis: 1) conditioning lesions promote earlier neurite initiation, 2) prior nerve injury decreases the ability of neurons to extend long neurites following a second axotomy, 3) exposure to the environment of a denervated peripheral nerve stimulates great...Continue Reading

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Citations

May 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Raffaella MolteniJeffery L Twiss
Mar 29, 2011·Annual Review of Neuroscience·Kai LiuZhigang He
Aug 14, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mathieu BoudesFrédérique Scamps
Sep 24, 2011·Journal of Neurotrauma·Supinder S BediEdgar T Walters
Jul 16, 2010·The Journal of Pain : Official Journal of the American Pain Society·Caitlin E HillJeffrey C Petruska
Aug 25, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C RadtkeP M Vogt
Sep 24, 2005·The European Journal of Neuroscience·Cécile HilaireFrédérique Scamps
Jan 19, 2007·The European Journal of Neuroscience·Peter J ShortlandLesley G Robson
Dec 14, 2004·Experimental Neurology·Michael D TaylorDouglas E Wright
Aug 16, 2005·Molecular and Cellular Neurosciences·Charles D MillsClifford J Woolf
Sep 14, 2010·Current Biology : CB·Andrea Tedeschi, Zhigang He
Feb 4, 2014·Journal of Neuroscience Methods·Luis E SavastanoSean I Patterson
Jun 9, 2009·Experimental Neurology·Christine Webber, Douglas Zochodne
Feb 25, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Budd A Tucker, Karen M Mearow
May 13, 2014·Cell Transplantation·Wise Young
Jan 25, 2018·Journal of Neural Engineering·Yuan RenDaniel M Suter
Jul 23, 2020·Molecular Neurobiology·Dominique LemaitreFelipe A Court
Feb 28, 2015·Advanced Healthcare Materials·Simone BonettiValentina Benfenati
Apr 12, 2000·Journal of Neurophysiology·M RenganathanS G Waxman
Nov 12, 2018·Cellular and Molecular Neurobiology·Elif Kaval Oğuz, Gürkan Öztürk
Jan 19, 2013·Annals of Plastic Surgery·Christine RadtkeJeffery D Kocsis
Apr 15, 2003·Molecular and Cellular Neurosciences·Per A R EkströmDavid A Tonge

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