May 2, 2014

Mechanisms of epigenetic memory

Trends in Genetics : TIG
Agustina D'Urso, Jason H Brickner

Abstract

Although genetics has an essential role in defining the development, morphology, and physiology of an organism, epigenetic mechanisms have an essential role in modulating these properties by regulating gene expression. During development, epigenetic mechanisms establish stable gene expression patterns to ensure proper differentiation. Such mechanisms also allow organisms to adapt to environmental changes and previous experiences can impact the future responsiveness of an organism to a stimulus over long timescales and even over generations. Here, we discuss the concept of epigenetic memory, defined as the stable propagation of a change in gene expression or potential induced by developmental or environmental stimuli. We highlight three distinct paradigms of epigenetic memory that operate on different timescales.

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  • Citations37

Citations

Mentioned in this Paper

Establishment and Maintenance of Localization
ISYNA1 gene
DNA Methylation [PE]
Nucleosomes
Histone antigen
PRC1 gene
Peroxisome Proliferator-Activated Receptors
Protein Methylation
Caenorhabditis elegans
Cataract, Nuclear Progressive

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