Mechanisms of epileptogenesis and preclinical approach to antiepileptogenic therapies

Pharmacological Reports : PR
Krzysztof ŁukawskiStanisław J Czuczwar

Abstract

The prevalence of epilepsy is estimated 5-10 per 1000 population and around 70% of patients with epilepsy can be sufficiently controlled by antiepileptic drugs (AEDs). Epileptogenesis is the process responsible for converting normal into an epileptic brain and mechanisms responsible include among others: inflammation, neurodegeneration, neurogenesis, neural reorganization and plasticity. Some AEDs may be antiepileptiogenic (diazepam, eslicarbazepine) but the correlation between neuroprotection and inhibition of epileptogenesis is not evident. Antiepileptogenic activity has been postulated for mTOR ligands, resveratrol and losartan. So far, clinical evidence gives some hope for levetiracetam as an AED inhibiting epileptogenesis in neurosurgical patients. Biomarkers for epileptogenesis are needed for the proper selection of patients for evaluation of potential antiepileptogenic compounds.

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Citations

Sep 1, 2018·Expert Opinion on Drug Safety·Romina MoaveroPaolo Curatolo
Feb 16, 2020·Phytotherapy Research : PTR·Ashish Dhir
Apr 2, 2020·International Journal of Molecular Sciences·Barbara MiziakStanisław J Czuczwar
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