PMID: 7035494Feb 1, 1982Paper

Mechanisms of epinephrine-induced glucose intolerance in normal humans

The Journal of Clinical Investigation
L SaccàR S Sherwin

Abstract

To evaluate the role of the splanchnic bed in epinephrine-induced glucose intolerance, we selectively assessed the components of net splanchnic glucose balance, i.e., splanchnic glucose uptake and hepatic glucose production, and peripheral glucose uptake by combining infusion of [3-(3)H]glucose with hepatic vein catheterization. Normal humans received a 90-min infusion of either glucose alone (6.5 mg/kg(-1) per min(-1)) or epinephrine plus glucose at two dose levels: (a) in amounts that simulated the hyperglycemia seen with glucose alone (3.0 mg/kg(-1) per min(-1)); and (b) in amounts identical to the control study. During infusion of glucose alone, blood glucose rose twofold, insulin levels and net posthepatic insulin release increased three- to fourfold, and net splanchnic glucose output switched from a net output (1.65+/-0.12 mg/kg(-1) per min(-1)) to a net uptake (1.56+/-0.18). This was due to a 90-95% fall (P < 0.001) in hepatic glucose production and a 100% rise (P < 0.001) in splanchnic glucose uptake (from 0.86+/-0.14 to 1.71+/-0.12 mg/kg(-1) per min(-1)), which in the basal state amounted to 30-35% of total glucose uptake. Peripheral glucose uptake rose by 170-185% (P < 0.001). When epinephrine was combined with the lo...Continue Reading

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R A DeFronzoP Felig
Nov 1, 1978·The Journal of Clinical Endocrinology and Metabolism·L SaccaR S Sherwin
Dec 1, 1979·The Journal of Clinical Endocrinology and Metabolism·J E Liljenquist, D Rabin
Jun 1, 1978·Metabolism: Clinical and Experimental·J RadziukJ Dupre
Jul 1, 1978·Metabolism: Clinical and Experimental·A D CherringtonM S Harris
Aug 1, 1978·The Journal of Clinical Investigation·G I ShulmanA D Cherrington
Mar 1, 1979·Metabolism: Clinical and Experimental·R R WolfeJ F Burke
Feb 26, 1976·The New England Journal of Medicine·R S SherwinP Felig
Feb 1, 1976·Metabolism: Clinical and Experimental·L Saccà, G Perez
Feb 1, 1973·Metabolism: Clinical and Experimental·P Felig
Aug 1, 1971·The Journal of Clinical Investigation·P Felig, J Wahren
Jan 1, 1967·Biochemistry·J Katz, A Dunn
Mar 1, 1980·The Journal of Clinical Investigation·R A RizzaJ E Gerich
Mar 1, 1980·The Journal of Clinical Investigation·D C Deibert, R A DeFronzo
Apr 1, 1980·The Journal of Clinical Endocrinology and Metabolism·L SaccàB Ungaro
Oct 1, 1980·Annals of Internal Medicine·S HamburgR S Sherwin
May 1, 1962·The Journal of Clinical Investigation·C M LEEVYM M HOWARD

❮ Previous
Next ❯

Citations

Apr 1, 1993·Diabetes/metabolism Reviews·S A Amiel
Dec 1, 1995·Diabetes/metabolism Reviews·B Capaldo, L Saccà
Jan 1, 1987·The International Journal of Biochemistry·A Page-PeñuelasF J Moreno
Mar 1, 1996·Journal of Clinical Epidemiology·N RavajaJ Viikari
Oct 1, 1992·Baillière's Clinical Endocrinology and Metabolism·R E Ferner
Apr 1, 1993·Baillière's Clinical Endocrinology and Metabolism·J Webber, I A Macdonald
Jan 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·K T MoriartyR B Tattersall
Jun 1, 1984·The Journal of Clinical Investigation·D C SimonsonR A DeFronzo
Jan 1, 1983·World Journal of Surgery·D S Gann, M P Lilly
Jan 1, 1988·Metabolism: Clinical and Experimental·E FerranniniR A DeFronzo
Feb 1, 1988·Diabetes/metabolism Reviews·W E ClutterP E Cryer
Feb 1, 1988·Diabetes/metabolism Reviews·S A AmielR S Sherwin
Mar 20, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Archana R SadhuMary E Herman
Oct 10, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Sandi-Jo GalatiWilliam B Inabnet
Jul 1, 1983·Clinics in Endocrinology and Metabolism·M C Rudolf, R S Sherwin
Feb 1, 1985·Metabolism: Clinical and Experimental·J D MillerM A Sperling
Dec 29, 2006·Annals of the New York Academy of Sciences·Evangelia Zapanti, Ioannis Ilias
Jul 16, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melissa A DavisSean W Limesand
Nov 1, 1983·The American Journal of Physiology·L SjöströmE Jéquier
Jun 15, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Bayan MesmarRana Malek
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Paolo ViciniClaudio Cobelli
Jul 1, 1988·The American Journal of Physiology·G A WertherM A Sperling
Feb 1, 1994·The American Journal of Physiology·G LemboL Saccá
Aug 1, 1984·The American Journal of Physiology·R S Sherwin, L Saccà
Sep 1, 1983·The American Journal of Physiology·L SaccàR S Sherwin
May 1, 1987·The American Journal of Physiology·M C PereF C Battaglia
Aug 1, 1985·The American Journal of Physiology·R NosadiniA Tiengo
Jul 18, 1984·Biochemical and Biophysical Research Communications·P ArnerJ Ostman
May 16, 1983·Biochemical and Biophysical Research Communications·P Lönnroth, U Smith
Sep 17, 2021·Journal of Neuroendocrinology·Laura L KoekkoekSusanne E la Fleur

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.