Mechanisms of epithelial fusion and repair

Nature Cell Biology
A JacintoP Martin

Abstract

One of the principal functions of any epithelium in the embryonic or adult organism is to act as a self-sealing barrier layer. From the earliest stages of development, embryonic epithelia are required to close naturally occurring holes and to fuse wherever two free edges are brought together, and at the simplest level that is precisely what the epidermis must do to repair itself wherever it is damaged. Parallels can be drawn between the artificially triggered epithelial movements of wound repair and the naturally occurring epithelial movements that shape the embryo during morphogenesis. Recent in vitro and in vivo wound-healing studies and analysis of paradigm morphogenetic movements in genetically tractable embryos, like those of Drosophila and Caenorhabditis elegans, have begun to identify both the signals that initiate these movements and the cytoskeletal machinery that drives motility. We are also gaining insight into the nature of the brakes and stop signals, and the mechanisms by which the confronting epithelial sheets knit together to form a seam.

References

Jun 1, 1992·The Journal of Clinical Investigation·M D HertleF M Watt
Jul 1, 1994·The Journal of Cell Biology·W M Brieher, B M Gumbiner
Jan 1, 1993·Genes & Development·P E YoungD P Kiehart
Nov 15, 1996·Science·M Tessier-Lavigne, C S Goodman
Feb 1, 1996·Cell Biology International·J P Heath
Oct 24, 1997·Science·J R Riesgo-Escovar, E Hafen
Jan 29, 1999·The Journal of Cell Biology·Y ZhongB M Gumbiner
Mar 24, 1999·The Journal of Cell Biology·C D Nobes, A Hall
May 14, 1999·Current Biology : CB·V ZecchiniA Martinez-Arias
Feb 9, 2000·The Journal of Cell Biology·B M Gumbiner
Sep 14, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K Woolley, P Martin
May 1, 1954·Experimental Cell Research·M ABERCROMBIE, J E HEAYSMAN

❮ Previous
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Citations

Jan 6, 2011·Cellular and Molecular Life Sciences : CMLS·Lin CaoMin Zhao
Feb 22, 2012·Cellular and Molecular Life Sciences : CMLS·Maria Teresa Abreu-BlancoSusan M Parkhurst
Dec 13, 2002·Nature·Sandrine Etienne-Manneville, Alan Hall
Feb 28, 2013·Nature Reviews. Molecular Cell Biology·João V Cordeiro, António Jacinto
Dec 21, 2002·Differentiation; Research in Biological Diversity·Vito Quaranta
Jan 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Joseph C PearsonWilliam McGinnis
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ester AnonBenoît Ladoux
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Liyu LiuRobert H Austin
Aug 31, 2010·The Journal of Biological Chemistry·Thuc Nghi NguyenSoichiro Yamada
Jul 25, 2008·Computer Methods in Biomechanics and Biomedical Engineering·G Wayne BrodlandJim H Veldhuis
Feb 3, 2005·Photomedicine and Laser Surgery·Daniel LevanonAvi Ravid
Feb 18, 2003·Molecular Biology of the Cell·Juana MagdalenaLaura M Machesky
May 4, 2007·Molecular Biology of the Cell·Derek A ApplewhiteGary G Borisy
May 14, 2010·Molecular Biology of the Cell·Ethan R BlockJes K Klarlund
Mar 20, 2008·Journal of the Royal Society, Interface·Monika RumplerPeter Fratzl
Aug 7, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Larry A Taber
Aug 6, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael J ReddPaul Martin
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Matthieu Cavey, Thomas Lecuit
Sep 17, 2003·Genes & Development·Hong ZhengBohdan Wasylyk
Sep 20, 2008·Science·Yusuke ToyamaGlenn S Edwards
Aug 6, 2010·American Journal of Physiology. Cell Physiology·Katherine R SchillerScott M O'Grady
Feb 26, 2010·Journal of Biomedicine & Biotechnology·Olga J Baker
Jun 19, 2010·Journal of Biomaterials Science. Polymer Edition·Dipendra GyawaliJian Yang
Jan 9, 2009·BMC Developmental Biology·Richard L MortJohn D West
Jun 26, 2009·Critical Care : the Official Journal of the Critical Care Forum·Marjo KoskelaVesa Koivukangas
Apr 3, 2012·Journal of Cell Science·Wenting Shih, Soichiro Yamada
Sep 15, 2012·Journal of Cell Science·Amanda R BrockMichael J Galko
Mar 29, 2008·PLoS Genetics·Rafael P Vázquez-ManriqueHoward A Baylis
Oct 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·M PoujadeP Silberzan
May 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Grégory BeauneFrançoise Brochard-Wyart
Aug 9, 2003·Critical Care Medicine·Joshua M V Mammen, Jeffrey B Matthews

❮ Previous
Next ❯

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