PMID: 9420048Jan 7, 1998Paper

Mechanisms of fluoroquinolone resistance in genetically related strains of Staphylococcus aureus

Antimicrobial Agents and Chemotherapy
G W Kaatz, S M Seo

Abstract

Fluoroquinolone resistance in Staphylococcus aureus results from amino acid substitutions at particular locations in the DNA gyrase A and B subunits as well as in the topoisomerase IV A subunit and from NorA-mediated efflux. More than one resistance mechanism may be present in a single strain. Fluoroquinolone-resistant derivatives of SA-1199, a methicillin-susceptible S. aureus strain, were selected in vivo or in vitro, and their mechanisms of fluoroquinolone resistance were identified. We found that many of the resistance mechanisms described above can develop in derivatives of a single parent strain, either singly or in combination, and can arise in a single step. Variances in MICs for strains with the same apparent resistance mechanisms likely are due to the presence of new or undetected but established means of fluoroquinolone resistance. NorA-mediated resistance can occur in the apparent absence of topoisomerase mutations and in some strains may be the result of a promoter region mutation causing increased expression of norA. However, increased expression of norA can occur independently of this mutation, suggesting that a regulatory locus for this gene exists elsewhere on the chromosome.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1991·Methods in Enzymology·R P Novick
May 1, 1991·The Journal of Infectious Diseases·G W KaatzC A Ruble
Sep 1, 1994·Antimicrobial Agents and Chemotherapy·H ItoS Nakamura
Jan 1, 1993·Antimicrobial Agents and Chemotherapy·A A NeyfakhG W Kaatz
Feb 1, 1993·Antimicrobial Agents and Chemotherapy·G M EliopoulosR C Moellering
May 1, 1993·Antimicrobial Agents and Chemotherapy·G W KaatzC A Ruble
Dec 1, 1995·Antimicrobial Agents and Chemotherapy·G W Kaatz, S M Seo

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Citations

Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Fred C TenoverBülent Bozdogan
Nov 16, 2020·International Journal of Antimicrobial Agents·Mark LawsMatthew E Wand
Jan 14, 2004·Drugs·Xian-Zhi Li, Hiroshi Nikaido
Sep 30, 2020·International Journal of Molecular Sciences·Rolando CannalireStefano Sabatini
Nov 29, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Joaquim RuizJordi Vila
Apr 10, 2013·The Open Microbiology Journal·Sofia Santos CostaIsabel Couto
Jun 19, 2002·Antimicrobial Agents and Chemotherapy·Laura J V PiddockMartin J Everett
Oct 3, 1999·Antimicrobial Agents and Chemotherapy·P N MarkhamA A Neyfakh
Oct 13, 2019·European Journal of Medicinal Chemistry·Feng GaoGang Huang
Jan 30, 1999·Antimicrobial Agents and Chemotherapy·J L Muñoz-BellidoJ A García-Rodríguez
Feb 13, 1999·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·S Jalal, B Wretlind
May 8, 2009·Bioorganic & Medicinal Chemistry·Siritron SamosornJohn B Bremner
Mar 16, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D A Talan
Jan 13, 2021·Antimicrobial Agents and Chemotherapy·Casey L CazerYrjö T Gröhn
Apr 9, 2001·The Journal of Pharmacy and Pharmacology·K Poole
Sep 14, 2002·Current Infectious Disease Reports·Md Rabiul AlamMarcus J. Zervos
Feb 7, 2014·Journal of Clinical Microbiology·N C GordonT Golubchik
May 27, 2005·Antimicrobial Agents and Chemotherapy·Jeffrey J CampionMartin E Evans
Apr 15, 2006·Clinical Microbiology Reviews·Laura J V Piddock
Jul 28, 2005·Natural Product Reports·Kate P LangtonRichard B Herbert
Feb 26, 2013·ChemMedChem·Anne Doléans-JordheimAhcène Boumendjel
May 14, 2008·Antimicrobial Agents and Chemotherapy·J M SierraJ Vila
Oct 30, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gary E SteinGlenn W Kaatz
Jan 30, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Tommaso FelicettiStefano Sabatini
Jul 18, 2006·Nature Reviews. Microbiology·Laura J V Piddock
Jun 20, 2007·Antimicrobial Agents and Chemotherapy·Carmen E DeMarcoGlenn W Kaatz
Feb 20, 2020·ChemMedChem·Rayssa M D da CruzFrancisco J B Mendonça-Junior
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Jeffrey J CampionMartin E Evans
Feb 19, 2002·Antimicrobial Agents and Chemotherapy·S RaherisonC M Bébéar
Nov 29, 2016·Expert Opinion on Therapeutic Targets·Clarissa WillersJosias Hendrik Hamman
Jul 6, 2020·Current Topics in Medicinal Chemistry·Kadja Luana Chagas MonteiroFrancisco Jaime B Mendonça Junior

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