Mechanisms of Glucocorticoid Action During Development

Current Topics in Developmental Biology
Jonathan T Busada, John A Cidlowski

Abstract

Glucocorticoids are primary stress hormones produced by the adrenal cortex. The concentration of serum glucocorticoids in the fetus is low throughout most of gestation but surge in the weeks prior to birth. While their most well-known function is to stimulate differentiation and functional development of the lungs, glucocorticoids also play crucial roles in the development of several other organ systems. Mothers at risk of preterm delivery are administered glucocorticoids to accelerate fetal lung development and prevent respiratory distress. Conversely, excessive glucocorticoid signaling is detrimental for fetal development; slowing fetal and placental growth and programming the individual for disease later in adult life. This review explores the mechanisms that control glucocorticoid signaling during pregnancy and provides an overview of the impact of glucocorticoid signaling on fetal development.

Citations

Jul 7, 2018·PloS One·Borja Romero-GonzalezMaria Isabel Peralta-Ramirez
Aug 17, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jin ZhouHui Wang
Jan 14, 2020·The Journal of Clinical Endocrinology and Metabolism·Valeria MessinaSvetlana Lajic
Feb 23, 2020·Animals : an Open Access Journal From MDPI·Sophia A WardKate J Plush
May 13, 2020·Stress : the International Journal on the Biology of Stress·Sofia A Lopez, Shelly B Flagel
May 14, 2020·Biology of Reproduction·Jie DongXiaohong Wang
Jul 28, 2020·Obstetric Medicine·Riccardo Pofi, Jeremy W Tomlinson
Sep 26, 2020·International Journal of Environmental Research and Public Health·John F OdhiamboStephen P Ford
Sep 28, 2018·Frontiers in Pharmacology·Waranya ChatuphonprasertIsabella Ellinger
Aug 6, 2020·International Journal of Environmental Research and Public Health·Aneta Słabuszewska-JóżwiakGrzegorz Jakiel
Oct 10, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ettore LignelliRory E Morty
Aug 6, 2020·Frontiers in Cell and Developmental Biology·Jens H WesthoffJochen Gehrig
Feb 13, 2021·Birth Defects Research·Bernice AsieduEliton Chivandi
Jan 30, 2021·Frontiers in Neuroscience·Mariana Astiz, Henrik Oster
Jun 3, 2021·International Journal of Molecular Sciences·Margaux LaulhéLaetitia Martinerie
Jun 2, 2021·European Journal of Clinical Investigation·Luís F GriloSusana P Pereira
Jul 23, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Lili LiuXin Sun
Aug 28, 2021·International Journal of Molecular Sciences·Negar MirJacqueline L Beaudry
Nov 25, 2021·Glia·Mariana AstizLaura López-Mascaraque

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Steroid Biochemistry and Molecular Biology
Andrea ConstantinofStephen G Matthews
Nature Reviews. Endocrinology
Vasilis G Moisiadis, Stephen G Matthews
Journal of Pediatric Endocrinology & Metabolism : JPEM
R J BoltH A Delemarre-van de Waal
Archives of Disease in Childhood. Fetal and Neonatal Edition
N ChooA M Perks
The Journal of Steroid Biochemistry and Molecular Biology
Pierre R ProvostYves Tremblay
© 2022 Meta ULC. All rights reserved