Mechanisms of glyceryl trinitrate provoked mast cell degranulation

Cephalalgia : an International Journal of Headache
Sara Hougaard PedersenI Jansen-Olesen

Abstract

Migraine patients develop attacks several hours after intravenous infusion of glyceryl trinitrate. Due to the short half-life of nitric oxide, this delayed migraine cannot be caused by a direct action of nitric oxide derived from glyceryl trinitrate. The involvement of meningeal inflammation and dural mast cell degranulation is supported by the effectiveness of prednisolone on glyceryl trinitrate-induced delayed headache. Using a newly developed rat model mimicking the human glyceryl trinitrate headache model, we have investigated the occurrence of dural mast cell degranulation after a clinically relevant dose of glyceryl trinitrate. A 6-fold increase in degranulation was observed starting at 2 hours after glyceryl trinitrate infusion. Interestingly, pre-treatment with the effective anti-migraine substances L-nitro-arginine methyl ester and sumatriptan prevented glyceryl trinitrate-induced mast cell degranulation whereas the calcitonin gene-related peptide-receptor antagonist olcegepant and the substance P receptor antagonist L-733,060 did not affect mast cell degranulation. However, topical application of two different nitric oxide donors did not cause mast cell degranulation ex vivo. Direct application of an exogenous nitric ...Continue Reading

References

Jun 1, 1991·Journal of Neurocytology·R V DimlichM J Fritts
Aug 1, 1984·Annals of Neurology·M A Moskowitz
Sep 1, 1982·British Journal of Pharmacology·C IoannidesI W Taylor
Feb 8, 1997·Lancet·L H LassenJ Olesen
May 1, 1997·Cephalalgia : an International Journal of Headache·A Ottosson, L Edvinsson
Jun 1, 1997·Cephalalgia : an International Journal of Headache·D J WilliamsonS L Shepheard
May 28, 1998·Cephalalgia : an International Journal of Headache·L H LassenJ Olesen
Oct 19, 1999·Cephalalgia : an International Journal of Headache·I ChristiansenJ Olesen
Nov 10, 2001·Brain : a Journal of Neurology·U ReuterM A Moskowitz
Apr 30, 2004·The Journal of Comparative Neurology·Andrew M StrassmanDan Levy
Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·David B MurrayJoseph S Janicki
Feb 4, 2005·Cephalalgia : an International Journal of Headache·N OffenhauserU Reuter
Oct 10, 2007·Immunology·Marianna KulkaRobert P Schleimer
Jul 21, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P Tfelt-HansenJ Olesen
Aug 14, 2009·Cephalalgia : an International Journal of Headache·C KruuseJ Olesen
Dec 17, 2011·Cephalalgia : an International Journal of Headache·Roshni RamachandranSaurabh Gupta
Jan 25, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·A VaratharajW Squier
Mar 17, 2012·Cephalalgia : an International Journal of Headache·Michael BaunInger Jansen-Olesen
Aug 21, 2013·The Journal of Pain : Official Journal of the American Pain Society·Sajedeh EftekhariLars Edvinsson
Sep 4, 2013·Cephalalgia : an International Journal of Headache·Roshni RamachandranJes Olesen
Sep 1, 1994·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L L ThomsenJ Olesen

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Citations

Jan 19, 2016·Neuroscience·Luiz F FerrariPaul G Green
Oct 27, 2009·Neuroscience Letters·Dorit PudRivka Pesta
Jul 26, 2017·Cephalalgia : an International Journal of Headache·Roshni RamachandranInger Jansen-Olesen
Jun 1, 2018·Cephalalgia : an International Journal of Headache·Shayne N HasslerGregory Dussor
Jan 19, 2018·Clinical and Experimental Pharmacology & Physiology·Erkan KilincFatma Tore
Jun 23, 2018·Cephalalgia : an International Journal of Headache·Dan LevyAntoinette MaassenVanDenBrink
Feb 21, 2018·The Journal of Headache and Pain·Inger Jansen-Olesen, Sara Hougaard Pedersen
Jul 26, 2019·Molecular Pain·Roshni RamachandranTony L Yaksh
Aug 18, 2020·Neuropsychiatric Disease and Treatment·Chang ZhouYonghui Pan
Mar 24, 2018·Seminars in Immunopathology·Roshni Ramachandran
Apr 16, 2019·Frontiers in Cellular Neuroscience·Sara Hougaard PedersenInger Jansen-Olesen
Sep 29, 2020·Frontiers in Cellular Neuroscience·Kseniia KorolevaGuzel Sitdikova
Nov 27, 2020·Journal of Neuroinflammation·Huaping XuLinbo Shi
Apr 2, 2021·Drug Development Research·Moein AlaAhmad Reza Dehpour

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GraphPad Prism
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