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Mechanisms of glycolytic inhibition in ischemic rat hearts
Circulation Research
Dec 1, 1975
Michael J RovettoJessica Neely
PMID: 157
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Abstract
The mechanisms of glycolytic inhibition in ischemic myocardium were investigated in the isolated, perfused rat heart. Glycolysis was inhibited at the level of glyceraldehyde-3-phosphate dehydrogenase. The major factors that accounted for the glycolytic inhibition in the ischemic heart c...read more
Mentioned in this Paper
Extracellular Space
Brain Hypoxia
Glyceraldehyde-3-phosphate dehydrogenase
Perfusion
Rat Heart
Lactates
Lactic Acid Measurement
Blood Flow Velocity
Glycolysis Inhibition
Anhydrous Dextrose
Paper Details
References
- References12
- Citations111
Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle
Annual Review of PhysiologyJanuary 1, 1974Jessica Neely, Hayley Morgan
The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver
The Biochemical JournalMay 1, 1967D H WilliamsonHans-Jakob Krebs
Myocardial utilization of carbohydrate and lipids
Progress in Cardiovascular DiseasesJanuary 1, 1972Jessica NeelyJ F OramThe effects of increased heart work on the tricarboxylate cycle and its interactions with glycolysis in the perfused rat heart
The Biochemical JournalJune 1, 1972Jessica NeelyP J. Randle
Regulation of glycolysis in the ischemic and the anoxic myocardium
Journal of Molecular and Cellular CardiologyDecember 1, 1970Wolfgang Michael Kübler, Paul Gerhard Spieckermann
Metabolic control characteristics of the acutely ischemic myocardium
The American Journal of CardiologySeptember 1, 1968A Wollenberger, Ernst-Georg KrauseEquilibrium relations between the cytoplasmic adenine nucleotide system and nicotinamide-adenine nucleotide system in rat liver
The Biochemical JournalApril 1, 1970Richard L VeechHans-Jakob KrebsRegulation of glucose uptake by muscle. 3. The effects of insulin, anoxia, salicylate and 2:4-dinitrophenol on membrane transport and intracellular phosphorylation of glucose in the isolated rat heart
The Biochemical JournalDecember 1, 1959Hayley MorganD M RegenControl of the redox state of the nicotinamide-adenine dinucleotide couple in rat liver cytoplasm
The Biochemical JournalJanuary 1, 1972Marion StubbsHans-Jakob KrebsMetabolic control of rat heart glycolysis after acute ischaemia. Fluoracetate treatment and thyroid interactions
Journal of Molecular and Cellular CardiologyAugust 1, 1971Rachel A Paterson
4
192
1
23
12
- References12
- Citations111
Factors determining the utilization of glucose in isolated rat hearts
Basic Research in CardiologyJanuary 1, 1984Hayley MorganYuji Kira
Superiority of acetate compared with lactate in a rodent model of severe hemorrhagic shock
The Journal of Surgical ResearchJanuary 1, 2014Ricarda RohrigHerbert de Groot
Prostacyclin prevents ischemia-induced increase of lactate and cyclic AMP in ischemic myocardium
European Journal of PharmacologyFebruary 19, 1981Renate RösenKarsten SchrörEnhanced lipolysis of myocardial triglycerides during low-flow ischemia and anoxia in the isolated rat heart
Basic Research in CardiologyMarch 1, 1989Kees SchoonderwoerdH Stam
Cardiac metabolism in the Myxinidae: physiological and phylogenetic considerations
Comparative Biochemistry and Physiology. A, Comparative PhysiologyJanuary 1, 1983Bruce D Sidell
Biochemical responses of the myocardium and red skeletal muscle to Salmonella typhimurium infection in the rat
Clinical PhysiologyDecember 1, 1983Nils-Gunnar IlbäckWilliam R BeiselEffects of hyperthermic stress on myocardial function during experimental coronary ischemia
Circulation ResearchNovember 1, 1976Andy J Liedtke, Howard C HughesEffect of oxygen withdrawal on active and passive electrical properties of arterially perfused rabbit ventricular muscle
Circulation ResearchMarch 1, 1989C B RieggerAndré G Kléber
Effects of antianginal drugs on myocardial energy metabolism in coronary artery disease
Pharmacology & ToxicologyJanuary 1, 1990Jens Peder Bagger
Comparison of acute alterations in left ventricular relaxation and diastolic chamber stiffness induced by hypoxia and ischemia. Role of myocardial oxygen supply-demand imbalance
The Journal of Clinical InvestigationJuly 1, 1981Toru SerizawaWilliam F Grossman
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Jessica NeelyMichael J Rovetto
Mechanisms of glycolytic inhibition in ischemic rat hearts
Abstract
The mechanisms of glycolytic inhibition in ischemic myocardium were investigated in the isolated, perfused rat heart. Glycolysis was inhibited at the level of glyceraldehyde-3-phosphate dehydrogenase. The major factors that accounted for the glycolytic inhibition in the ischemic heart c...read more
Mentioned in this Paper
Extracellular Space
Brain Hypoxia
Glyceraldehyde-3-phosphate dehydrogenase
Perfusion
Rat Heart
Related Papers
Paper Details
References
- References12
- Citations111
Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle
Annual Review of PhysiologyJanuary 1, 1974Jessica Neely, Hayley MorganThe redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver
The Biochemical JournalMay 1, 1967D H WilliamsonHans-Jakob KrebsMyocardial utilization of carbohydrate and lipids
Progress in Cardiovascular DiseasesJanuary 1, 1972Jessica NeelyJ F OramThe effects of increased heart work on the tricarboxylate cycle and its interactions with glycolysis in the perfused rat heart
The Biochemical JournalJune 1, 1972Jessica NeelyP J. RandleRegulation of glycolysis in the ischemic and the anoxic myocardium
Journal of Molecular and Cellular CardiologyDecember 1, 1970Wolfgang Michael Kübler, Paul Gerhard SpieckermannMetabolic control characteristics of the acutely ischemic myocardium
The American Journal of CardiologySeptember 1, 1968A Wollenberger, Ernst-Georg KrauseEquilibrium relations between the cytoplasmic adenine nucleotide system and nicotinamide-adenine nucleotide system in rat liver
The Biochemical JournalApril 1, 1970Richard L VeechHans-Jakob KrebsRegulation of glucose uptake by muscle. 3. The effects of insulin, anoxia, salicylate and 2:4-dinitrophenol on membrane transport and intracellular phosphorylation of glucose in the isolated rat heart
The Biochemical JournalDecember 1, 1959Hayley MorganD M RegenControl of the redox state of the nicotinamide-adenine dinucleotide couple in rat liver cytoplasm
The Biochemical JournalJanuary 1, 1972Marion StubbsHans-Jakob KrebsMetabolic control of rat heart glycolysis after acute ischaemia. Fluoracetate treatment and thyroid interactions
Journal of Molecular and Cellular CardiologyAugust 1, 1971Rachel A Paterson
4
192
1
23
12
- References12
- Citations111
Factors determining the utilization of glucose in isolated rat hearts
Basic Research in CardiologyJanuary 1, 1984Hayley MorganYuji KiraSuperiority of acetate compared with lactate in a rodent model of severe hemorrhagic shock
The Journal of Surgical ResearchJanuary 1, 2014Ricarda RohrigHerbert de GrootProstacyclin prevents ischemia-induced increase of lactate and cyclic AMP in ischemic myocardium
European Journal of PharmacologyFebruary 19, 1981Renate RösenKarsten SchrörEnhanced lipolysis of myocardial triglycerides during low-flow ischemia and anoxia in the isolated rat heart
Basic Research in CardiologyMarch 1, 1989Kees SchoonderwoerdH StamCardiac metabolism in the Myxinidae: physiological and phylogenetic considerations
Comparative Biochemistry and Physiology. A, Comparative PhysiologyJanuary 1, 1983Bruce D SidellBiochemical responses of the myocardium and red skeletal muscle to Salmonella typhimurium infection in the rat
Clinical PhysiologyDecember 1, 1983Nils-Gunnar IlbäckWilliam R BeiselEffects of hyperthermic stress on myocardial function during experimental coronary ischemia
Circulation ResearchNovember 1, 1976Andy J Liedtke, Howard C HughesEffect of oxygen withdrawal on active and passive electrical properties of arterially perfused rabbit ventricular muscle
Circulation ResearchMarch 1, 1989C B RieggerAndré G KléberEffects of antianginal drugs on myocardial energy metabolism in coronary artery disease
Pharmacology & ToxicologyJanuary 1, 1990Jens Peder BaggerComparison of acute alterations in left ventricular relaxation and diastolic chamber stiffness induced by hypoxia and ischemia. Role of myocardial oxygen supply-demand imbalance
The Journal of Clinical InvestigationJuly 1, 1981Toru SerizawaWilliam F Grossman
12345...
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