Mechanisms of glycolytic inhibition in ischemic rat hearts
Circulation Research
Dec 1, 1975
M J RovettoJ R Neely
PMID: 157
Abstract
The mechanisms of glycolytic inhibition in ischemic myocardium were investigated in the isolated, perfused rat heart. Glycolysis was inhibited at the level of glyceraldehyde-3-phosphate dehydrogenase. The major factors that accounted for the glycolytic inhibition in the ischemic heart c...read more
Mentioned in this Paper
GAPDH gene
Hydrogen-Ion Concentration
Lactic Acid Measurement
Myocardial Stunning
Metabolic Inhibition
Glycolysis Inhibition
Brain Hypoxia
Intracellular Fluid
Lactates
Hypoxia
1
Paper Details
References
- References16
- Citations115
On the fate of glycogen phosphorylase in the ischemic and infarcting myocardium
Journal of Molecular and Cellular CardiologyAugust 1, 1971W SchulzeA Wollenberger
Metabolic control characteristics of the acutely ischemic myocardium
The American Journal of CardiologySeptember 1, 1968A Wollenberger, E G Krause
Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle
Annual Review of PhysiologyJanuary 1, 1974J R Neely, H E Morgan110
The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver
The Biochemical JournalMay 1, 1967D H WilliamsonH A Krebs51651Control of the redox state of the nicotinamide-adenine dinucleotide couple in rat liver cytoplasm
The Biochemical JournalJanuary 1, 1972M StubbsH A Krebs
THE EFFECT OF COENZYME Q0 ON POTASSIUM TRANSPORT IN THE EHRLICH ASCITES-TUMOR CELL
Biochimica Et Biophysica ActaMarch 30, 1964S W WEINSTEIN, H G HEMPLINGRegulation of glycolysis in the ischemic and the anoxic myocardium
Journal of Molecular and Cellular CardiologyDecember 1, 1970W Kübler, P G SpieckermannRegulation of glucose uptake by muscle. 3. The effects of insulin, anoxia, salicylate and 2:4-dinitrophenol on membrane transport and intracellular phosphorylation of glucose in the isolated rat heart
The Biochemical JournalDecember 1, 1959H E MorganD M REGENThe effects of increased heart work on the tricarboxylate cycle and its interactions with glycolysis in the perfused rat heart
The Biochemical JournalJune 1, 1972J R NeelyP J RANDLE27
Myocardial utilization of carbohydrate and lipids
Progress in Cardiovascular DiseasesNovember 1, 1972J R NeelyJ F Oram
12
- References16
- Citations115
Cardiac metabolism in the Myxinidae: physiological and phylogenetic considerations
Comparative Biochemistry and Physiology. A, Comparative PhysiologyJanuary 1, 1983B D Sidell
Changes in glycogenolysis in the ischemic zone in experimental myocardial infarct
Biulleten' eksperimental'noĭ biologii i meditsinyMarch 1, 1980N P DolgovaChronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells
Biochimica Et Biophysica ActaMarch 7, 2013Alexander V ZhdanovDmitri B Papkovsky
Development of an ex vivo technique to achieve reanimation of hearts sourced from a porcine donation after circulatory death model
The Journal of Surgical ResearchApril 4, 2014Omar A MownahDavid TalbotGlucose metabolism during ischemia due to excessive oxygen demand or altered coronary flow in the isolated arterially perfused rabbit septum
Circulation ResearchSeptember 1, 1981R C MarshallN Ricchiuti
Metabolic determinants of electrical failure in ex-vivo canine model of cardiac arrest: evidence for the protective role of inorganic pyrophosphate
PloS OneMarch 23, 2013Junko ShibayamaAlexey V Zaitsev216Effects of insulin on glucose metabolism in isolated heart myocytes from adult rats
Biochimica Et Biophysica ActaSeptember 30, 1985V ChenJ J SpitzerIntraoperative myocardial protection in the context of coronary revascularization
Progress in Cardiovascular DiseasesMay 1, 1987N A Silverman, S Levitsky
Pressor sensitivity to angiotensin I and angiotensin II during the development of experimental renal hypertension in the rat
Clinical and Experimental Pharmacology & PhysiologyJuly 1, 1986A E DoyleJ TorresiSubstrate effects in the post-ischemic myocardium
The Journal of Surgical ResearchApril 1, 1988E Y SakoJ E Foker
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Related Papers
Mechanisms of glycolytic inhibition in ischemic rat hearts
Abstract
The mechanisms of glycolytic inhibition in ischemic myocardium were investigated in the isolated, perfused rat heart. Glycolysis was inhibited at the level of glyceraldehyde-3-phosphate dehydrogenase. The major factors that accounted for the glycolytic inhibition in the ischemic heart c...read more
Mentioned in this Paper
GAPDH gene
Hydrogen-Ion Concentration
Lactic Acid Measurement
Myocardial Stunning
Metabolic Inhibition
Glycolysis Inhibition
Brain Hypoxia
Intracellular Fluid
Lactates
Hypoxia
1
Related Papers
Paper Details
References
- References16
- Citations115
On the fate of glycogen phosphorylase in the ischemic and infarcting myocardium
Journal of Molecular and Cellular CardiologyAugust 1, 1971W SchulzeA WollenbergerMetabolic control characteristics of the acutely ischemic myocardium
The American Journal of CardiologySeptember 1, 1968A Wollenberger, E G KrauseRelationship between carbohydrate and lipid metabolism and the energy balance of heart muscle
Annual Review of PhysiologyJanuary 1, 1974J R Neely, H E Morgan110The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver
The Biochemical JournalMay 1, 1967D H WilliamsonH A Krebs51651Control of the redox state of the nicotinamide-adenine dinucleotide couple in rat liver cytoplasm
The Biochemical JournalJanuary 1, 1972M StubbsH A KrebsTHE EFFECT OF COENZYME Q0 ON POTASSIUM TRANSPORT IN THE EHRLICH ASCITES-TUMOR CELL
Biochimica Et Biophysica ActaMarch 30, 1964S W WEINSTEIN, H G HEMPLINGRegulation of glycolysis in the ischemic and the anoxic myocardium
Journal of Molecular and Cellular CardiologyDecember 1, 1970W Kübler, P G SpieckermannRegulation of glucose uptake by muscle. 3. The effects of insulin, anoxia, salicylate and 2:4-dinitrophenol on membrane transport and intracellular phosphorylation of glucose in the isolated rat heart
The Biochemical JournalDecember 1, 1959H E MorganD M REGENThe effects of increased heart work on the tricarboxylate cycle and its interactions with glycolysis in the perfused rat heart
The Biochemical JournalJune 1, 1972J R NeelyP J RANDLE27Myocardial utilization of carbohydrate and lipids
Progress in Cardiovascular DiseasesNovember 1, 1972J R NeelyJ F Oram
12
- References16
- Citations115
Cardiac metabolism in the Myxinidae: physiological and phylogenetic considerations
Comparative Biochemistry and Physiology. A, Comparative PhysiologyJanuary 1, 1983B D SidellChanges in glycogenolysis in the ischemic zone in experimental myocardial infarct
Biulleten' eksperimental'noĭ biologii i meditsinyMarch 1, 1980N P DolgovaChronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells
Biochimica Et Biophysica ActaMarch 7, 2013Alexander V ZhdanovDmitri B PapkovskyDevelopment of an ex vivo technique to achieve reanimation of hearts sourced from a porcine donation after circulatory death model
The Journal of Surgical ResearchApril 4, 2014Omar A MownahDavid TalbotGlucose metabolism during ischemia due to excessive oxygen demand or altered coronary flow in the isolated arterially perfused rabbit septum
Circulation ResearchSeptember 1, 1981R C MarshallN RicchiutiMetabolic determinants of electrical failure in ex-vivo canine model of cardiac arrest: evidence for the protective role of inorganic pyrophosphate
PloS OneMarch 23, 2013Junko ShibayamaAlexey V Zaitsev216Effects of insulin on glucose metabolism in isolated heart myocytes from adult rats
Biochimica Et Biophysica ActaSeptember 30, 1985V ChenJ J SpitzerIntraoperative myocardial protection in the context of coronary revascularization
Progress in Cardiovascular DiseasesMay 1, 1987N A Silverman, S LevitskyPressor sensitivity to angiotensin I and angiotensin II during the development of experimental renal hypertension in the rat
Clinical and Experimental Pharmacology & PhysiologyJuly 1, 1986A E DoyleJ TorresiSubstrate effects in the post-ischemic myocardium
The Journal of Surgical ResearchApril 1, 1988E Y SakoJ E Foker
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