Mechanisms of Hearing Loss in a Guinea Pig Model of Superior Semicircular Canal Dehiscence

Neural Plasticity
Bu-Sheng TongDong-Dong Ren

Abstract

Defective acoustic transmission in the cochlea is closely related with various auditory and vestibular symptoms. Among them, semicircular canal dehiscence (SCD) with a defective semicircular bone is typical. Currently, the pathogenesis of SCD is usually explained by the third window hypothesis; however, this hypothesis fails to explain the variability in the symptoms and signs experienced by superior SCD (SSCD) patients. We evaluated the mechanism of hearing loss in a guinea pig model of bony dehiscence with various sizes and locations along the superior semicircular canal. Auditory brainstem responses (ABRs) and laser Doppler velocimetry were used to measure hearing loss and vibration changes before and after fenestration, as well as after restorative patching. ABR thresholds at low frequencies (e.g., 1000 Hz) increased after fenestration and decreased back to the normal range after we repaired the defect. Energy leakage from the surgically introduced third window was detected in the range of 300-1500 Hz, accompanied by increased vibration at the umbo, stapes head, and the dehiscence site, while decreased vibration was observed at the round window membrane in the same frequency range. After the patching procedure, the deviant ...Continue Reading

References

Apr 3, 1998·Archives of Otolaryngology--head & Neck Surgery·L B MinorD S Zee
Feb 19, 2000·Archives of Otolaryngology--head & Neck Surgery·J P CareyG T Nager
Mar 7, 2003·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Lloyd B MinorMichael J Ruckenstein
Dec 31, 2003·Hearing Research·Kenneth R WhittemoreJohn J Rosowski
Mar 17, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Anthony A MikulecSaumil N Merchant
May 7, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·John J RosowskiSaumil N Merchant
Oct 14, 2005·The Laryngoscope·Lloyd B Minor
Sep 29, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Charles J LimbLloyd B Minor
Jan 25, 2007·Advances in Oto-rhino-laryngology·Saumil N MerchantMichael J McKenna
Aug 4, 2007·The Journal of the Acoustical Society of America·Jocelyn E Songer, John J Rosowski
Jan 29, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Saumil N Merchant, John J Rosowski
Jul 31, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Gunesh P RajanRobert K Eikelboom
May 28, 2009·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Andre JakobThomas Zahnert
Nov 26, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Heng-Wai YuenMarcus D Atlas
Jan 6, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Fang-Lu ChiChun-Fu Dai
Feb 2, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Alain PfammatterThomas Linder
Jul 20, 2010·Hearing Research·Jocelyn E Songer, John J Rosowski
May 24, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Joseph AttiasMichal Preis
Oct 22, 2014·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Angela WenzelJohn P Carey
Dec 23, 2014·Audiology & Neuro-otology·Marlien E F NiestenHideko Heidi Nakajima
May 21, 2015·International Archives of Otorhinolaryngology·Emidio Oliveira Teixeira, Marconi Teixeira Fonseca
Nov 4, 2015·The Laryngoscope·Michihiko SoneShinji Naganawa
Jan 14, 2017·Journal of Neurosurgery·Wenya Linda BiIan F Dunn

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Jan 25, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Tyler MiaoQuinton Gopen

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