Mechanisms of hormesis through mild heat stress on human cells

Annals of the New York Academy of Sciences
S I Rattan

Abstract

In a series of experimental studies, it was shown that repetitive mild heat stress has antiaging hormetic effects on growth and various other cellular and biochemical characteristics of human skin fibroblasts undergoing aging in vitro. We have reported the hormetic effects of repeated challenge at the levels of maintenance of stress protein profile; reduction in the accumulation of oxidatively and glycoxidatively damaged proteins; stimulation of the proteasomal activities for the degradation of abnormal proteins; improved cellular resistance to ethanol, hydrogen peroxide, and ultraviolet-B rays; and enhanced levels of various antioxidant enzymes. Detailed analysis of the signal transduction pathways to determine alterations in the phosphorylation and dephosphorylation states of ERK, JNK, and p38 MAP kinases as a measure of cellular responsiveness to mild and severe heat stress is in progress. Furthermore, comparative studies using nonaging immortal cell lines, such as SV40-transformed human fibroblasts, spontaneous osteosarcoma cells, and telomerase-immortalized human bone marrow cells are also in progress for establishing differences in normal and cancerous cells for their responsiveness to mild and severe stresses.

References

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Aug 24, 2001·Cell Biology International·P VerbekeS I Rattan
Mar 16, 2002·Journal of Applied Physiology·Vladimir L Gabai, Michael Y Sherman
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Citations

Feb 8, 2006·Biogerontology·J Krøll
May 28, 2011·Tissue Engineering. Part a·Cecilia OseraAlessia Pascale
Dec 15, 2010·Nutrition & Metabolism·Alistair V NunnJimmy D Bell
Apr 19, 2012·Expert Opinion on Drug Discovery·Suresh I S Rattan
Oct 28, 2008·Molecular Reproduction and Development·S Clay IsomEdmund B Rucker
Jun 29, 2006·Annals of the New York Academy of Sciences·Sorin RigaFlorin Halalau
Jun 12, 2010·Annals of the New York Academy of Sciences·Geneviève MorrowRobert M Tanguay
Jan 1, 2010·Cell Biology International Reports·Pamela PetrocchiRoberta Possenti
Jun 10, 2015·Journal of Receptor and Signal Transduction Research·Colin G Rousseaux, Stephanie F Greene
Aug 10, 2013·Dose-response : a Publication of International Hormesis Society·Guanghu Wang
Apr 29, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Patrick HeinrichThomas Braunbeck
May 16, 2008·Human & Experimental Toxicology·Edward J Calabrese
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Haw-Yueh Thong, Howard I Maibach
Feb 28, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eszter Herczenik, Martijn F B G Gebbink
Aug 8, 2007·Ciência & saúde coletiva·Ralph Cook, Edward J Calabrese
Nov 17, 2006·Environmental Health Perspectives·Ralph Cook, Edward J Calabrese
Jan 20, 2007·The Journal of Experimental Biology·Alice R A Villalobos, J Larry Renfro

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