Mechanisms of HTLV-1 transformation

Frontiers in Bioscience : a Journal and Virtual Library
Kylene KehnF Kashanchi

Abstract

HTLV-1 is the etiological agent of the fatal disease adult T-cell leukemia. The virus encodes many proteins including several accessory proteins, p12I, p13II, p27I, and p30II, whose roles have recently begun to be elucidated. These accessory proteins are important in T-cell activation, transcriptional regulation, viral persistence, and virus assembly. The viral oncogene Tax is thought to be largely responsible for tumorigenesis, although the precise mechanisms underlying transformation are not completely understood. Tax has a profound impact on transcription, cell growth regulation, genomic stability and apoptosis. This review will provide possible contributions of the accessory proteins to transformation as well as highlight the alterations of the above-mentioned cellular events by Tax. Animal models of both Tax and the accessory proteins are also included based on the essential information on the transformation process in vivo that they provide.

Citations

Sep 19, 2007·International Journal of Hematology·Jean-Marie PeloponeseKuan-Teh Jeang
Nov 11, 2011·Journal of Virology·Peter WimmerThomas Dobner
Sep 13, 2005·Oncogene·Shao-Cong Sun, Shoji Yamaoka
Sep 13, 2005·Oncogene·Fatah Kashanchi, John N Brady
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seung-Jae KimMichael D Lairmore
Feb 19, 2010·Journal of Virology·Rebecca EasleyFatah Kashanchi
Aug 11, 2006·Retrovirology·Anne PumferyFatah Kashanchi

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