Mechanisms of human embryo development: from cell fate to tissue shape and back.

Development
Marta N Shahbazi

Abstract

Gene regulatory networks and tissue morphogenetic events drive the emergence of shape and function: the pillars of embryo development. Although model systems offer a window into the molecular biology of cell fate and tissue shape, mechanistic studies of our own development have so far been technically and ethically challenging. However, recent technical developments provide the tools to describe, manipulate and mimic human embryos in a dish, thus opening a new avenue to exploring human development. Here, I discuss the evidence that supports a role for the crosstalk between cell fate and tissue shape during early human embryogenesis. This is a critical developmental period, when the body plan is laid out and many pregnancies fail. Dissecting the basic mechanisms that coordinate cell fate and tissue shape will generate an integrated understanding of early embryogenesis and new strategies for therapeutic intervention in early pregnancy loss.

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Citations

Aug 12, 2020·Nature Communications·Marta N ShahbaziMagdalena Zernicka-Goetz
Mar 6, 2021·Stem Cell Reports·Janet Rossant, Patrick P L Tam
May 1, 2021·Nature Reviews. Molecular Cell Biology·Hui Yi Grace Lim, Nicolas Plachta
May 1, 2021·International Journal of Molecular Sciences·Kasturi MarkandranChristine Cheung
Apr 30, 2021·Development·Ersin AkinciRichard I Sherwood
May 30, 2021·Developmental Cell·Tien Phan-EversonEric D Siggia
Jul 4, 2021·Trends in Plant Science·Bing Bai
Jul 14, 2021·Seminars in Cell & Developmental Biology·Julie Firmin, Jean-Léon Maître
Aug 18, 2021·ELife·Kirsty Ml MackinlayMagdalena Zernicka-Goetz
Aug 28, 2021·Cells·Paola RebuzziniSilvia Garagna

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Methods Mentioned

BETA
imaging techniques

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