Mechanisms of hysteresis in human brain networks during transitions of consciousness and unconsciousness: Theoretical principles and empirical evidence

PLoS Computational Biology
Hyoungkyu KimUnCheol Lee

Abstract

Hysteresis, the discrepancy in forward and reverse pathways of state transitions, is observed during changing levels of consciousness. Identifying the underlying mechanism of hysteresis phenomena in the brain will enhance the ability to understand, monitor, and control state transitions related to consciousness. We hypothesized that hysteresis in brain networks shares the same underlying mechanism of hysteresis as other biological and non-biological networks. In particular, we hypothesized that the principle of explosive synchronization, which can mediate abrupt state transitions, would be critical to explaining hysteresis in the brain during conscious state transitions. We analyzed high-density electroencephalogram (EEG) that was acquired in healthy human volunteers during conscious state transitions induced by the general anesthetics sevoflurane or ketamine. We developed a novel method to monitor the temporal evolution of EEG networks in a parameter space, which consists of the strength and topography of EEG-based networks. Furthermore, we studied conditions of explosive synchronization in anatomically informed human brain network models. We identified hysteresis in the trajectory of functional brain networks during state tra...Continue Reading

References

Oct 12, 2001·Nature·M SchefferB Walker
May 15, 2004·Progress in Biophysics and Molecular Biology·Moira L Steyn-RossJ W Sleigh
Sep 27, 2006·Anesthesia and Analgesia·George A Mashour
Mar 16, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·G FilatrellaK Wiesenfeld
Apr 19, 2007·Journal of Biological Rhythms·A J K Phillips, P A Robinson
Jun 27, 2009·Journal of Mathematical Biology·Michael J RempeDavid Terman
Oct 31, 2009·Proceedings of the National Academy of Sciences of the United States of America·Roberto CaminitiGiorgio M Innocenti
Apr 27, 2011·Physical Review Letters·Jesús Gómez-GardeñesYamir Moreno
Dec 15, 2011·European Journal of Pharmacology·Logan J VossJames W Sleigh
Nov 17, 2012·Brain Connectivity·Anthony G Hudetz
Jul 12, 2013·PLoS Computational Biology·Melanie I Stefan, Nicolas Le Novère
Aug 16, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Xiyun ZhangZonghua Liu
Jul 9, 2014·Frontiers in Systems Neuroscience·George A Mashour
Jul 30, 2014·Frontiers in Systems Neuroscience·Stefanie Blain-MoraesGeorge A Mashour
Sep 19, 2014·Anesthesiology·Oluwaseun AkejuPatrick L Purdon
Oct 9, 2014·Anesthesiology·Stefanie Blain-MoraesGeorge A Mashour
Feb 7, 2015·Physical Review Letters·Xiyun ZhangZonghua Liu
Apr 16, 2015·PLoS Computational Biology·Joon-Young MoonGeorge A Mashour
Aug 31, 2016·Physical Review. E·Xiyun ZhangZonghua Liu
Feb 24, 2017·Nature Neuroscience·Michael Breakspear
Jul 18, 2017·Frontiers in Computational Neuroscience·Minkyung KimUnCheol Lee
Jul 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Francisco J FloresPatrick L Purdon
Mar 6, 2018·Frontiers in Human Neuroscience·Hyoungkyu KimUNKNOWN ReCCognition Study Group
Apr 24, 2018·Anesthesiology·UnCheol Lee, George A Mashour
Jun 12, 2018·Neuron·Honghui ZhangJoshua Jacobs
Jun 25, 2018·British Journal of Anaesthesia·U Lee, G A Mashour
Jun 25, 2018·British Journal of Anaesthesia·A Proekt, A E Hudson

❮ Previous
Next ❯

Citations

Mar 19, 2019·Anesthesia and Analgesia·Max B KelzKen Solt
Apr 30, 2020·Journal of Neurosurgical Anesthesiology·Andrew R McKinstry-WuMax B Kelz
Sep 3, 2019·Frontiers in Systems Neuroscience·Vincent BonhommeOlivia Gosseries
Feb 12, 2020·Network Neuroscience·MinKyung Kim, UnCheol Lee
Feb 18, 2021·Scientific Reports·Catherine DuclosStefanie Blain-Moraes
Jan 10, 2021·International Journal of Molecular Sciences·Sarah Eagleman, M Bruce MacIver
Oct 22, 2020·British Journal of Anaesthesia·Alex Proekt, Max B Kelz
Apr 14, 2021·NeuroImage·Zirui HuangAnthony G Hudetz
Dec 29, 2020·Biochemical Pharmacology·Gratia Nguyen, Svetlana Postnova
Jul 18, 2021·Physical Review. E·Mousumi RoyChittaranjan Hens
Feb 5, 2022·Anesthesiology·George A MashourUnCheol Lee
Feb 5, 2022·Anesthesiology·Rebecca M PullonJamie W Sleigh

❮ Previous
Next ❯

Software Mentioned

MATLAB
EEGLAB
MATLAB Signal Processing Toolbox

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.