Mechanisms of immune evasion in breast cancer

BMC Cancer
Joshua P BatesTonya J Webb

Abstract

Tumors develop multiple mechanisms of immune evasion as they progress, with some cancer types being inherently better at 'hiding' than others. With an increased understanding of tumor immune surveillance, immunotherapy has emerged as a promising treatment strategy for breast cancer, despite historically being thought of as an immunologically silent neoplasm. Some types of cancer, such as melanoma, bladder, and renal cell carcinoma, have demonstrated a durable response to immunotherapeutic intervention, however, breast neoplasms have not shown the same efficacy. The causes of breast cancer's immune silence derive from mechanisms that diminish immune recognition and others that promote strong immunosuppression. It is the mechanisms of immune evasion in breast cancers that are poorly defined. Thus, further characterization is critical for the development of better therapies. This brief review will seek to provide insight into the possible causes of weak immunogenicity and immune suppression mediated by breast cancers and highlight current immunotherapies being used to restore immune responses to breast cancer.

References

Nov 1, 1996·The Journal of Experimental Medicine·M E van den BroekH Hengartner
Mar 31, 2000·Nature Medicine·R A ClynesJ V Ravetch
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Jan 18, 2003·International Journal of Cancer. Journal International Du Cancer·Mitsuhiko IwamotoNobuhiko Tanigawa
Dec 22, 2004·Journal of Surgical Oncology·Soji F OluwoleHector A DePaz
May 3, 2005·Nature Reviews. Cancer·Richard A Lake, Bruce W S Robinson
Dec 21, 2005·The Journal of Experimental Medicine·Noelia CasaresGuido Kroemer
Jan 7, 2006·Nature Reviews. Cancer·Karin E de VisserLisa M Coussens
May 10, 2006·Nature Clinical Practice. Oncology·Rita NahtaFrancisco J Esteva
May 30, 2006·Advances in Immunology·Charles G DrakeDrew M Pardoll
Dec 6, 2006·Cancer·Emad A RakhaIan O Ellis
Dec 26, 2006·Nature Medicine·Michel ObeidGuido Kroemer
Dec 29, 2006·The New England Journal of Medicine·Charles E GeyerDavid Cameron
Jan 11, 2007·The Journal of Experimental Medicine·Bin ZhangHans Schreiber
Mar 28, 2007·Immunology·Ryungsa KimKazuaki Tanabe
May 4, 2007·The Journal of Clinical Investigation·Jeremy B Swann, Mark J Smyth
Dec 22, 2007·Nature Reviews. Immunology·Laurence ZitvogelGuido Kroemer
Mar 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonino MusolinoAndrea Ardizzoni
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sylvain LadoireFrançois Ghiringhelli
Jun 3, 2008·Journal of Leukocyte Biology·Michele W L TengMark J Smyth
Jun 21, 2008·The New England Journal of Medicine·Olivera J Finn
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brandon L PierceCornelia M Ulrich
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carsten DenkertGunter von Minckwitz
Mar 12, 2010·Nature·Massimo AmmiranteMichael Karin
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Johan StaafAke Borg
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
May 19, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert H VonderheideSusan M Domchek
Jan 12, 2011·Annual Review of Immunology·Matthew D VeselyMark J Smyth
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 26, 2011·The Journal of Pathology·Sylvain LadoireFrançois Ghiringhelli
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sahar M A MahmoudAndrew R Green
May 24, 2011·Cancer Research·Jitka FucikovaRadek Spísek
Jun 3, 2011·The Journal of Clinical Investigation·Brian D LehmannJennifer A Pietenpol
Jul 7, 2011·The British Journal of Dermatology·S Rangwala, K Y Tsai
Aug 16, 2011·The Journal of Clinical Investigation·Emilie MamessierDaniel Olive
Sep 13, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Marco ErreniPaola Allavena
Dec 14, 2011·The New England Journal of Medicine·José BaselgaUNKNOWN CLEOPATRA Study Group

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Citations

Jul 12, 2018·International Journal of Cancer. Journal International Du Cancer·Zhongnan YinLixiang Xue
Nov 15, 2018·The Journal of Pathology·Amy E McCart ReedSunil R Lakhani
Mar 7, 2019·The Journal of Pathology·Ralph H HrubanLaura D Wood
Oct 28, 2019·Oncoimmunology·Jenny SprootenAbhishek D Garg
May 1, 2020·Cancer Immunology, Immunotherapy : CII·Koushan Sineh SepehrSeyed Mahmoud Hashemi
Jun 4, 2020·International Journal of Cancer. Journal International Du Cancer·Hedda von der Lippe GythfeldtOlav Engebraaten
Jul 15, 2020·The Journal of Clinical Investigation·Catherine OleschAndreas Weigert
Jul 31, 2020·Scientific Reports·Erick Andrés Muciño-OlmosOsbaldo Resendis-Antonio
Oct 22, 2020·Cell Death & Disease·Justyna MączyńskaGabriela Kramer-Marek
Jul 25, 2020·Advanced Drug Delivery Reviews·Dennis HuangNicholas A Peppas
Sep 22, 2020·Archives of Biochemistry and Biophysics·Zhi Xiong ChongWan Yong Ho
Jan 19, 2021·European Journal of Pharmacology·Patience SetordziDaiying Zuo
Feb 4, 2021·Bioengineering & Translational Medicine·Debra WuSamir Mitragotri
Mar 9, 2021·Frontiers in Veterinary Science·Guillermo ValdiviaLaura Peña
Jan 14, 2021·American Journal of Physiology. Cell Physiology·Hannah E WilsonEmidio E Pistilli
Apr 8, 2021·Immunotherapy·Ramon Andrade de MelloJosé Antonio Silva
May 1, 2021·Diagnostics·Joanna SzporDiana Hodorowicz-Zaniewska
Jun 14, 2021·Oncogene·Xia LiuGuangyong Peng
Aug 28, 2021·Pharmacology & Therapeutics·Luying ZhangVojtech Adam
Sep 17, 2021·Journal of Cancer Research and Therapeutics·Ruby DharSubhradip Karmakar

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Methods Mentioned

BETA
xenograft

Clinical Trials Mentioned

NCT01358877
NCT02689427
NCT03055312
NCT00468715
NCT02303366
NCT02499367
NCT02538471
NCT01862900
NCT01421017
NCT01874353

Software Mentioned

GeparSixto

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