Mechanisms of immunotherapy: IgG revisited

Current Opinion in Allergy and Clinical Immunology
Petra A Wachholz, S R Durham

Abstract

This paper will review historical and recent evidence for the induction of 'blocking' IgG antibodies during successful specific immunotherapy. Specific immunotherapy is frequently associated with a rise in allergen-specific IgG4 antibodies and a modest reduction in specific IgE titres, although this does not always correlate with clinical efficacy. There is accumulating evidence that specific immunotherapy also influences the blocking activity on IgE-mediated responses by IgG4, and cellular assays are commonly used to investigate these changes. Recently, a novel assay, which detects allergen-IgE binding using flow cytometry, has been used to detect 'functional' specific immunotherapy-induced changes in IgG antibody activity. Results suggest that successful specific immunotherapy is associated with an increase in IgG blocking activity that is not solely dependent on the quantity of IgG antibodies. Successful immunotherapy is associated with quantitative and qualitative changes in the allergen-specific IgG antibody response. The induction of IgG antibodies with blocking activity may have a protective role not only through the inhibition of allergen-induced, IgE-mediated release of inflammatory mediators from mast cells and basoph...Continue Reading

References

Sep 1, 1992·The Journal of Allergy and Clinical Immunology·D B GoldenL M Lichtenstein
Jan 1, 1992·The Journal of Allergy and Clinical Immunology·E Jensen-JarolimB M Stadler
Mar 1, 1995·Allergy·G C MuddeC A Bruijnzeel-Koomen
Aug 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P W EwanP J Lachmann
Sep 27, 1993·Journal of Immunological Methods·P LambinD A Levy
Mar 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J DuchateauL Baras
Jun 25, 1998·Current Opinion in Immunology·K M Coggeshall
Jul 25, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A MichilsJ Duchateau
Sep 2, 1998·The Journal of Allergy and Clinical Immunology·S R Durham, S J Till
May 21, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A MichilsJ Duchateau
May 26, 1999·International Archives of Allergy and Immunology·C Ebner
Jun 26, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R ValentaH Grönlund
Jul 31, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T BallR Valenta
Mar 13, 2001·Annual Review of Immunology·J V Ravetch, S Bolland
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T P KingM D Spangfort
Jun 26, 2001·Journal of the American Academy of Dermatology·G Stingl
Aug 21, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S VrtalaR Valenta
Aug 21, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M FockeR Valenta
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·P W Ewan
Jul 9, 2002·Allergy·U R Müller
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Birgit LinhartRudolf Valenta
Sep 5, 2002·European Journal of Immunology·Sabine FlickerRudolf Valenta
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Natalija NovakThomas Bieber
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Petra A WachholzStephen R Durham
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kayhan T Nouri-AriaStephen R Durham
Mar 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J J van NeervenP A Würtzen
Nov 30, 1935·The Journal of Experimental Medicine·R A CookeA Stull

❮ Previous
Next ❯

Citations

Jun 6, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H OttH F Merk
Jun 17, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H OttH F Merk
Jul 24, 2012·Seminars in Immunopathology·Rima Rachid, Dale T Umetsu
Aug 11, 2006·Current Allergy and Asthma Reports·Steven J McEldowney, Robert K Bush
Mar 9, 2005·The Journal of Allergy and Clinical Immunology·David B K Golden
May 3, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Samuele E BurasteroRenato E Rossi
Oct 31, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Halina PlewakoSabina Rak
Mar 20, 2012·Parasitology·Angela van DiepenCornelis H Hokke
Aug 1, 2007·The Journal of Experimental Medicine·Hozefa S BandukwalaAnne I Sperling
Mar 3, 2010·Annual Review of Immunology·Rudolf ValentaSusanne Vrtala
Sep 1, 2006·International Archives of Allergy and Immunology·Gabriela SentiThomas M Kundig
Jul 3, 2008·International Archives of Allergy and Immunology·Christian MöbsMichael Hertl
Oct 4, 2011·Clinical and Molecular Allergy : CMA·Laurie S DavisDavid A Khan
Sep 15, 2008·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Cevdet OzdemirCezmi A Akdis
Mar 14, 2012·Clinical and Translational Allergy·Hiroyuki FujitaCezmi A Akdis
Feb 16, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Nadine MothesSusanne Spitzauer
Feb 17, 2011·Immunotherapy·Beatrice M Bilò, Floriano Bonifazi
Jan 1, 2010·The Libyan Journal of Medicine·Yousef A TaherAntoon J M van Oosterhout
Sep 11, 2014·Current Opinion in Otolaryngology & Head and Neck Surgery·Chengshuo Wang, Luo Zhang
Apr 20, 2012·Immunotherapy·Michael B SoykaCezmi A Akdis
Feb 18, 2014·International Immunopharmacology·Kriti GuptaPremendra D Dwivedi
Sep 5, 2014·Immunotherapy·Caterina CuppariCarmelo Salpietro
Oct 4, 2005·Expert Opinion on Biological Therapy·Axel Roers, Nicolas Hunzelmann
Jan 21, 2016·Expert Review of Clinical Immunology·Ludger KlimekPascal Demoly
Feb 9, 2016·The Journal of Allergy and Clinical Immunology·Marek JutelCezmi A Akdis
Jan 22, 2013·Allergologia et immunopathologia·M AlvaroUNKNOWN Sociedad Española de Inmunología Clínica y Alergia Pediátrica (SEICAP)
Nov 1, 2015·European Journal of Immunology·Sumithra SubramaniamGraham Ogg
Feb 11, 2012·Allergologia et immunopathologia·M F Martín-MuñozUNKNOWN SEICAP Immunotherapy Work Group
Jan 27, 2012·The Journal of Allergy and Clinical Immunology·Jean Christoph CaubetAnna Nowak-Węgrzyn
Jan 17, 2012·Immunology and Allergy Clinics of North America·Jean-Christoph Caubet, Hugh A Sampson
Apr 16, 2011·The Journal of Allergy and Clinical Immunology·Adnan CustovicPatrick G Holt
Mar 8, 2011·The Journal of Allergy and Clinical Immunology·Jens HolmKaare Lund
Jul 14, 2010·The Journal of Allergy and Clinical Immunology·Christina UermösiMartin F Bachmann
Feb 27, 2007·The Journal of Allergy and Clinical Immunology·Mübeccel Akdis, Cezmi A Akdis
May 17, 2006·Immunology and Allergy Clinics of North America·Johan VerhagenMübeccel Akdis
Dec 1, 2015·Immunology and Allergy Clinics of North America·Philippe Moingeon
Dec 1, 2015·Immunology and Allergy Clinics of North America·Julie ChesnéJulia Esser von-Bieren
Oct 20, 2005·Clinical and Experimental Immunology·J FendtP T Soboslay

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.