Mechanisms of impaired growth: effect of steroids on bone and cartilage

Hormone Research
Robert C Olney

Abstract

Long-term treatment with high-dose glucocorticoids (GCs) has profound effects on bone metabolism and linear growth. Bone metabolism is a balance between bone resorption by osteoclasts and new bone formation by osteoblasts. Systemically, GC treatment reduces circulating levels of estrogen and modestly increases parathyroid hormone levels. At the local level, GCs decrease insulin-like growth factor I (IGF-I) production, induce IGF-I resistance and increase nuclear factor kappaB ligand production by osteoblasts. These alterations inhibit new bone formation and stimulate bone resorption, with a net loss of bone over time. Clinically, this results in decreased bone mineral density, osteoporosis and increased risk for fracture. Local effects of GCs at the growth plate include reduction of IGF-I production, inducing IGF-I resistance and reducing production of C-type natriuretic peptide, which results in a reduction of chondrocyte proliferation, matrix synthesis and hypertrophy. These reductions in chondrocyte function result in decreased linear growth. The effects of GCs on bone metabolism and linear growth are sensitive and specific and represent an evolutionary adaptation to redirect resources during times of physiologic stress. Sin...Continue Reading

Citations

Apr 16, 2014·The Journal of Pediatrics·Alan D Rogol, Gregory F Hayden
Oct 16, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xin ChengXuesong Yang
Jun 18, 2011·Clinics in Dermatology·Daisuke TsurutaTakashi Hashimoto
May 17, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Raj Mitra
Apr 22, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anna RufoAnna Teti
Apr 24, 2012·British Journal of Clinical Pharmacology·Heather J DowningRosalind L Smyth
Sep 16, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lesley Rees
Oct 7, 2014·Toxicology and Applied Pharmacology·Xin ChengXuesong Yang
Jul 29, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dieter Haffner, Miroslav Zivicnjak
Jul 19, 2012·Journal of Child Neurology·Jennifer TangtiphaiboontanaHeather J Fullerton
May 16, 2018·Clinical Nuclear Medicine·Ekaterina TiktinskyJoseph Kapelushnik
Nov 6, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Qian TangCory J Xian
Dec 7, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Leanne M Ward, David R Weber
Mar 18, 2020·Scandinavian Journal of Gastroenterology·Ellen HuldénPer Swärd
Mar 21, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Adriana SuhlrieUNKNOWN German Society of Paediatric Nephrology
Jan 17, 2021·Calcified Tissue International·Fernando SantosDieter Haffner
Mar 6, 2021·Orphanet Journal of Rare Diseases·Stephanie KourakisEmma Rybalka

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