Mechanisms of improved physical performance of chronic hemodialysis patients after erythropoietin treatment

American Journal of Nephrology
M GrunzeJ Bommer

Abstract

Correction of the anemia that is common among chronic hemodialysis patients by treatment with human recombinant erythropoietin (rHuEPO), even if incomplete, improves physical performance of patients. Oxygen uptake and physical work capacity at maximal work loads and at the anaerobic threshold increase by approximately 20%. Analysis of underlying mechanisms by pulmonary function tests and ergospirometry demonstrate that improved oxygen transport in the blood and its concomitant changes of the anaerobic threshold and heart rate appear to be main causes of improvement. Parameters of respiratory mechanics and gas exchange remain essentially unaltered.

Citations

Jan 12, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kiyoshi MaekawaYoshiki Nishizawa
Sep 29, 2001·Kidney International·K L JohansenP Painter
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Feb 6, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kirsten L JohansenTracy J Mayne
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