Mechanisms of impulse generation in isolated cells from the rabbit sinoatrial node.

Journal of Molecular and Cellular Cardiology
H I OeiL N Bouman

Abstract

The contribution to spontaneous activity of three currents INa, If, and Isi was investigated in isolated spontaneously active SA nodal cells. It was demonstrated that isolated cells have electrophysiological properties similar to those of cells in the intact node. Evidence for the contributory role of INa to the upstroke of the action potential was obtained from membrane responsiveness curves and from the observation that Vmax was strongly reduced after the addition of 9 microM TTX to the bathing solution. The relative role of If and Isi as depolarizing diastolic membrane currents was investigated by relating the maximal density of each of these currents to the corresponding DDR during spontaneous activity. Both currents If and Isi-peak appear to be linearly related to DDR, indicating their contributory role to diastolic depolarization. Although the cells studied were heterogeneous with regard to the density of If and Isi we found no evidence for their separation into distinct groups of pacemaker cell types.

Citations

Sep 11, 1998·Journal of Cardiovascular Pharmacology·T M VinogradovaL V Rosenshtraukh
Mar 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sebastian K G MaierTodd Scheuer
Jul 17, 2007·Médecine sciences : M/S·Guy Lerebours
Apr 5, 2003·Circulation Research·Marieke W VeldkampArthur A M Wilde
Jul 31, 2014·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dennis K Helling, Samuel G Johnson
Jul 16, 2008·Physiological Reviews·Matteo E Mangoni, Joël Nargeot
Mar 1, 1995·Chaos·Michael R. Guevara, Timothy J. Lewis
Feb 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Trine Krogh-MadsenMichael R Guevara
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Yasutaka KurataToshishige Shibamoto
Mar 1, 1994·The American Journal of Physiology·S S DemirW R Giles

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