Mechanisms of in vivo muscle fatigue in humans: investigating age-related fatigue resistance with a computational model

The Journal of Physiology
Damien M CallahanJane A Kent

Abstract

Muscle fatigue can be defined as the transient decrease in maximal force that occurs in response to muscle use. Fatigue develops because of a complex set of changes within the neuromuscular system that are difficult to evaluate simultaneously in humans. The skeletal muscle of older adults fatigues less than that of young adults during static contractions. The potential sources of this difference are multiple and intertwined. To evaluate the individual mechanisms of fatigue, we developed an integrative computational model based on neural, biochemical, morphological and physiological properties of human skeletal muscle. Our results indicate first that the model provides accurate predictions of fatigue and second that the age-related resistance to fatigue is due largely to a lower reliance on glycolytic metabolism during contraction. This model should prove useful for generating hypotheses for future experimental studies into the mechanisms of muscle fatigue. During repeated or sustained muscle activation, force-generating capacity becomes limited in a process referred to as fatigue. Multiple factors, including motor unit activation patterns, muscle fibre contractile properties and bioenergetic function, can impact force-generatin...Continue Reading

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Citations

Oct 19, 2016·Medicine and Science in Sports and Exercise·Jane A KentTimothy I Musch
Jun 3, 2017·PLoS Computational Biology·Jim R Potvin, Andrew J Fuglevand
Mar 2, 2018·Journal of Applied Physiology·Christopher W SundbergSandra K Hunter
Nov 1, 2016·Journal of Applied Physiology·Sandra K HunterKevin G Keenan
Sep 24, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Slim ZarzissiThomas J Hureau

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