Mechanisms of increased airway microvascular permeability: role in airway inflammation and obstruction

Clinical and Experimental Pharmacology & Physiology
R G Goldie, K E Pedersen

Abstract

1. Airway inflammation is a signal feature of human asthma, as is bronchial obstruction and the resultant airflow limitation. An obligatory accompaniment to airway inflammation is increased airway microvascular permeability, which in turn is causally related to bronchial oedema. In this review, we have attempted to describe the mechanisms of increased airway microvascular permeability and its relationship to oedema, bronchial obstruction and the hyperreactivity to spasmogenic stimuli which are such common features of asthma. 2. It is now clear that bronchial obstruction in chronic asthma can involve bronchial wall oedema and swelling in addition to reversible, elevated airway smooth muscle tone, mucus hypersecretion and airway plugging and potentially permanent structural changes in airway architecture. Inflammatory mediators released in the airway wall in asthma including histamine, platelet-activating factor, leukotrienes and bradykinin are potent inducers of increased bronchial microvascular permeability and are thus promoters of bronchial oedema, airway wall swelling and reduction in luminal calibre. 3. The primary mechanism believed to underlie acute increases in microvascular permeability is contraction of post-capillary ...Continue Reading

References

Apr 15, 1979·European Journal of Pharmacology·C G Persson, I Erjefält
Aug 1, 1977·Postgraduate Medical Journal·T J David
May 1, 1992·The Journal of Clinical Investigation·R RabinoviciG Feuerstein
Oct 20, 1992·European Journal of Pharmacology·H P KuoP J Barnes
Jun 1, 1992·The American Review of Respiratory Disease·B R WiggsJ C Hogg
Jan 1, 1992·British Medical Bulletin·D F Rogers, T W Evans
Jul 1, 1992·American Journal of Respiratory Cell and Molecular Biology·G H DownieM Friedman
Nov 1, 1991·The American Review of Respiratory Disease·P J BarnesM G Belvisi
Oct 1, 1990·Journal of Applied Physiology·J O LötvallK F Chung
Dec 4, 1990·European Journal of Pharmacology·S R HughesS D Brain
Aug 6, 1991·European Journal of Pharmacology·J O LötvallK F Chung
May 1, 1991·The American Review of Respiratory Disease·I Erjefält, C G Persson
Jul 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T BrunnéeC R Baumgarten
Feb 1, 1991·The American Review of Respiratory Disease·P M RenziJ G Martin
Jun 1, 1991·The American Review of Respiratory Disease·K TokuyamaK F Chung
Jan 25, 1991·European Journal of Pharmacology·K TokuyamaK F Chung
Mar 1, 1990·The American Review of Respiratory Disease·R G Goldie
May 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L GreiffC G Persson
Feb 1, 1986·Lancet·P J Barnes
Dec 1, 1987·The American Review of Respiratory Disease·R Uddman, F Sundler
Jul 7, 1988·European Journal of Pharmacology·Z KhalilR D Helme
Jun 1, 1989·British Journal of Clinical Pharmacology·C M Dixon, P J Barnes
Feb 1, 1989·The American Review of Respiratory Disease·P BoschettoP J Barnes
Sep 1, 1989·Journal of Applied Physiology·A Wanner
Aug 1, 1988·The American Review of Respiratory Disease·T W EvansP J Barnes
Nov 15, 1986·Lancet·C G Persson
Jan 1, 1988·Lung·C G Persson
Mar 1, 1988·The American Review of Respiratory Disease·D ProudR M Naclerio

❮ Previous
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Citations

Aug 15, 1997·Regulatory Peptides·L O CardellJ A Nadel
Jun 24, 1999·The Journal of Urology·D E BjorlingR Saban
Oct 25, 2008·Circulation Research·Julius AitsebaomoCam Patterson
Nov 4, 2000·American Journal of Respiratory Cell and Molecular Biology·C G LeeJ A Elias
Oct 6, 2010·Respiratory Research·Andrea ZaniniDario Olivieri
Jul 25, 2014·Drugs·Rachid Berair, Christopher E Brightling
Oct 10, 2013·COPD·Sofia NikolakopoulouPetros Bakakos
Oct 29, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y H KhorE H Walters
Nov 17, 2010·Molecular and Cellular Endocrinology·V K KouritasC Hatzoglou
Jun 14, 2017·Journal of Cellular and Molecular Medicine·Louise Margaret HarknessJanette Kay Burgess
Dec 27, 2005·The Pediatric Infectious Disease Journal·Azzeddine DakhamaErwin W Gelfand
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Mar 27, 2001·Pediatric Emergency Care·M BitsoriS Sbyrakis
Apr 29, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Saeko NomuraJunichi Yoshikawa
Jun 16, 2001·Ultrastructural Pathology·V V Polosukhin
Jan 7, 2017·Journal of Veterinary Science·Ann Kristin BartonHeidrun Gehlen
Aug 20, 2021·Journal of Asthma and Allergy·Jack T WombleJennifer L Ingram

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